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THE RATE OF NOREPINEPHRINE SYNTHESIS MEASURED IN VIVO DURING SHORT INTERVALS; INFLUENCE OF ADRENERGIC NERVE IMPULSE ACTIVITY
Abstract
Tyrosine-C 14 was administrated i.v. at different rates to unanesthetized rats. Accumulation of norepinephrine-C 14 was determined in the heart, brain and submaxillary glands. A technique is described which allows calculation of norepinephrine synthesis rates from the ratio of norepinephrine-C 14 content and mean specific tyrosine activity. Estimated synthesis rates were higher than expected from previous determinations of norepinephrine turnover rates. It is suggested that the turnover rate of norepinephrine may not measure its true synthesis rate. Norepinephrine formation in the submaxillary gland was reduced to insignificant values after sympathetic denervation. The technique was also applied to the estimation of changes in norepinephrine synthesis after alterations of adrenergic nerve impulse activity. Sympathetic decentralization diminished, whereas nerve stimulation accelerated, norepinephrine synthesis in the submaxillary gland of the unanesthetized rat.
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Cited by
Esler, M., Jennings, G., Korner, P., Willett, I., Dudley, F., Hasking, G., Anderson, W., & Lambert, G. (1988) · Hypertension · doi:10.1161/01.hyp.11.1.3 · Cited by 642
Depletion of brain noradrenaline and dopamine by 6‐hydroxydopamine
BREESE, G. R., & TRAYLOR, T. D. (1971) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1971.tb07089.x · Cited by 527
Brain amines and models of experimental hypertension.
Chalmers, J. P. (1975) · Circulation Research · doi:10.1161/01.res.36.4.469 · Cited by 329
Breese, G. R., Cott, J. M., Cooper, B. R., Prange, A. J., Lipton, M. A., & Plotnikoff, N. P. (1975) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30117-5 · Cited by 293
Landsberg, L., Greff, L., Gunn, S., & Young, J. B. (1980) · Metabolism · doi:10.1016/0026-0495(80)90022-0 · Cited by 47
Metadata
- Authors
- Sedvall, G. C., Weise, V. K., & Kopin, I. J.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1968-02
- Volume
- 159
- Issue
- 2
- Pages
- 274-282
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2099269179
- Cited by
- 175
- References
- 0
- FWCI
- 15.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE RATE OF NOREPINEPHRINE SYNTHESIS MEASURED IN VIVO DURING SHORT INTERVALS; INFLUENCE OF ADRENERGIC NERVE IMPULSE ACTIVITY. https://app.cochat.ai/papers/10.1016/s0022-3565(25)27868-5
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- Sedvall, G. C., Weise, V. K., & Kopin, I. J. (1968). THE RATE OF NOREPINEPHRINE SYNTHESIS MEASURED IN VIVO DURING SHORT INTERVALS; INFLUENCE OF ADRENERGIC NERVE IMPULSE ACTIVITY. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1016/s0022-3565(25)27868-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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