Effects of fentanyl on vasopressin secretion in human subjects.
Abstract
To test the influence of an opioid on vasopressin (AVP) secretion, plasma AVP concentration was measured in five semirecumbent unmedicated volunteers before and during two continuous i.v. infusions of fentanyl. Infusion rates were adjusted to produce steady-state plasma fentanyl concentrations of 2.0 +/- 0.4 and 4.1 +/- 0.6 ng/ml; mild to moderate hypercarbia was induced during the control and infusion periods. Fentanyl increased plasma AVP concentration in a dose-dependent manner to 559 +/- 215 and 929 +/- 199% of the basal level of 1.9 +/- 0.7 pg/ml. Neither mild hypercarbia (PCO2 = 50 +/- 1 mm Hg) in the absence of fentanyl nor moderate hypercarbia (PCO2 = 66 +/- 3 mm Hg) in the presence of fentanyl changed plasma AVP concentration. Neither fentanyl nor hypercarbia, nor the combination of the two, altered plasma renin activity.
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Fentanyl increased AVP release in both surgical patients and healthy volunteers.
“Fentanyl increased AVP release in both surgical patients (166) and healthy volunteers (167).”
From Exogenous Opioids and the Human Endocrine System: An Endocrine Society Scientific Statement (2024) · cites this paper as [167]
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Cited by 17
- Authors
- Weiskopf, R. B., Reid, I. A., Fisher, D. M., Holmes, M. A., Rosen, J. I., & Keil, L. C.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Weiskopf, R B
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1987-09
- Volume
- 242
- Issue
- 3
- Pages
- 970-973
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2271531707
- Cited by
- 17
- References
- 0
- Citations by year
- 2024: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Funders
- National Heart, Lung, and Blood Institute (HL29714)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- fentanyl, vasopressin release, hypercapnia, plasma renin activity, carbon dioxide tension
- MeSH terms
- Adult, Blood Pressure, Carbon Dioxide, Fentanyl, Humans, Male, Morphine, Renin, Vasopressins
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