The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The relationship between fibromyalgia and interstitial cystitis
Open accessAbstract
Interstitial cystitis (IC) is a relatively uncommon and enigmatic disorder characterized by pain in the bladder and pelvic region, typically accompanied by urinary urgency and frequency. Fibromyalgia is a more common disorder, with the prominent symptoms being diffuse musculoskeletal pain and fatigue, and it has been well established that there is substantial clinical overlap between fibromyalgia and chronic fatigue syndrome (CFS). Although genitourinary and musculoskeletal symptoms predominate in IC and fibromyalgia respectively, both disorders share a number of features, including similar demographics, "allied conditions" (e.g. irritable bowel syndrome, headaches, etc.), natural history, aggravating factors, and efficacious therapy. We hypothesized that there was substantial clinical overlap between fibromyalgia and IC, and examined cohorts of individuals with these two disorders in parallel, to compare the spectrum of symptomatology. Sixty fibromyalgia patients, 30 IC patients, and 30 age-matched healthy controls were questioned regarding current symptomatology. A dolorimeter examination was also performed in the three groups to assess peripheral nociception. We found that the frequency of current symptoms was very similar for the fibromyalgia and IC groups. Both the fibromyalgia and IC patients displayed increased pain sensitivity when compared to healthy individuals, at both tender and control points. These data suggest that IC and fibromyalgia have significant overlap in symptomatology, and that IC patients display diffusely increased peripheral nociception, as is seen in fibromyalgia. Although central mechanisms have been suspected to contribute to the pathogenesis of fibromyalgia for some time, we speculate that these same types of mechanisms may be operative in IC, which has traditionally been felt to be a bladder disorder.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Accordingly, and due also to the similarities of the symptoms with CSS, IC is also considered a CSS [9,49].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [49]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563
Gillenwater, J. Y., & Wein, A. J. (1988) · The Journal of Urology · doi:10.1016/s0022-5347(17)41529-1 · Cited by 754
The Natural History of Interstitial Cystitis: A Survey of 374 Patients
Koziol, J. A., Clark, D. C., Gittes, R. F., & Tan, E. M. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)36120-7 · Cited by 351
Aspects of fibromyalgia in the general population: sex, pain threshold, and fibromyalgia symptoms.
Wolfe, F., Ross, K., Anderson, J. J., & Russell, I. J. (1995) · PubMed · Cited by 341
EPIDEMIOLOGY OF INTERSTITIAL CYSTITIS
Koziol, J. A. (1994) · Urologic Clinics of North America · doi:10.1016/s0094-0143(21)00587-5 · Cited by 321
Granges, G., & Littlejohn, G. O. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360510 · Cited by 257
Reactive fibromyalgia syndrome
Greenfield, S. A., Fitzcharles, M., & Esdaile, J. M. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780350612 · Cited by 138
The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia
Claliw, D. J. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90263-5 · Cited by 121
AMITRIPTYLINE IN THE TREATMENT OF INTERSTITIAL CYSTITIS
Hanno, P. M. (1994) · Urologic Clinics of North America · doi:10.1016/s0094-0143(21)00596-6 · Cited by 102
Boissevain, M. D., & McCain, G. A. (1991) · Pain · doi:10.1016/0304-3959(91)90048-3 · Cited by 101
Research works printed but not linked: 2
- Clauw, 1995, Fibromyalgia: more than a musculoskeletal disease, Am Fam Phys, 52, 843
- Gillenwater, 1988, 140, 203
Cited by
Sorted by citations
Items 201–230 of 230
Université de Poitiers Faculté de Médecine et Pharmacie
Couderc, E. (2014)
Review Articles COMORBIDITY OF INTERSTITIAL CYSTITIS WITH OTHER UNEXPLAINED CLINICAL CONDITIONS
Buffington, C. A. T. (2004)
Syndrome de la douleur vésicale/cystite interstitielle : physiopathologie, diagnostic et traitement
Mouracadé, P., & SAUSSINE, C. (2010) · Annales d Urologie · doi:10.1016/s1762-0953(10)53634-3
Interstitial cystitis/bladder pain syndrome
Wang, A. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107478084.010
Syndrome de la douleur vésicale/cystite interstitielle
Mouracadé, P., & SAUSSINE, C. (2012) · EMC - Gynécologie · doi:10.1016/s0246-1064(12)70036-1
Painful Bladder Syndrome/Interstitial Cystitis
Stanford, E. J., & Hinote, C. (2010) · CRC Press eBooks · doi:10.3109/9781439807217-53
Nitrosative Stress in Diverse Multisystem Diseases
Freye, E. C. K. (2011) · Springer eBooks · doi:10.1007/978-94-007-2036-7_7
Myofascial trigger point pain and fibromyalgia syndromes
Baldry, P., & Thompson, J. W. (2005) · Elsevier eBooks · doi:10.1016/b978-044306644-3.50011-5
Chronic Pelvic Pain of Urogynecologic Origin
Echols, K. T., Toidze, T. V., & Simpkins, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-45794-9_8
Reviewing Interstitial Cystitis Models and Treatments: A Focus on the Urothelium
Federico, F. (2017) · Razavi International Journal of Medicine · doi:10.5812/rijm.64551
Análise de polimorfismos de nucleotídeo único na cistite intersticial
Cassao, V. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-26032018-130655
Chapter 90 – NEUROENDOCRINE ROLE IN INTERSTITIAL CYSTITIS AND CHRONIC PELVIC PAIN IN WOMEN
Buffington, C. A. T. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-2339-5.50139-7
Hughes, L. (2019) · DigitalCommons@UNMC
Chaitow, L., Baldry, P., Blake, E., Dommerholt, J., Good, R., Issa, T. S., Lowe, J. C., McMakin, C., McPartland, J. M., Watson, P., et al. (2009) · Elsevier eBooks · doi:10.1016/b978-0-443-06936-9.00015-9
Hemisomatic Central Sensitivity Pain Disorder (“Hemi-fibromyalgia Syndrome”)
Pappolla, M. A. (2017) · Pain Management Case Reports · doi:10.36076/pmcr.2017/1/181
The Functional Syndromes as Fibromyalgia Comorbidities
Atzeni, F., Gerratana, E., Masala, I. F., & Alciati, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-78638-0_12
Genitourinary Pain and Inflammation in Rheumatic Diseases
Husni, M. E., & Calabrese, L. H. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-126-4_9
Treatment of Interstitial Cystitis/Bladder Pain Syndrome with Palmitoylethanolamide/Polydatin
Gubbiotti, M., Rosadi, S., & Giannantoni, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-94174-1_23
RE: DIURNAL CORTISOL VARIATIONS AND SYMPTOMS IN PATIENTS WITH INTERSTITIAL CYSTITIS
Buffington, T. (2002) · The Journal of Urology · doi:10.1097/00005392-200211000-00071
Wesselmann, U. (2003) · CRC Press eBooks · doi:10.1201/9780203911259.ch20
(2015) · Elsevier eBooks · doi:10.1016/b978-3-437-31618-0.16001-8
Hanno, P. M. (2012) · Springer eBooks · doi:10.1007/978-1-4419-6929-3_1
Integration: what seems to be helping?
(2003) · Elsevier eBooks · doi:10.1016/b978-0-443-07219-2.50016-5
Muscle Pain, Fibromyalgia Syndrome (Primary, Secondary)
Russell, I. J. (2006) · Springer eBooks · doi:10.1007/978-3-540-29805-2_2532
TEMPORAL ANALYSIS OF THE PREVALENCE OF OSTEOARTICULAR PAIN AND MENTAL HEALTH
Marques, M. A. A., de Oliveira, B. G., Corsini, A. R., Filho, C. A. D. M., Resident Doctor Psiquiatria Pela Secretária Municipal De Saúde De Vitória Da Conquista, B., Peixoto, P. P. D. A., Holtz, F. N., Nerys, R. C., da Silva, L. C. P., & Simões, M. R. C. (2023) · The American Journal of Medical Sciences and Pharmaceutical Research · doi:10.37547/tajmspr/volume05issue11-05
van Ophoven, A., & Oberpenning, F. (2006) · Der Urologe · doi:10.1007/s00120-006-1021-y
Chen, J.-L., Zhou, X., Liu, B.-L., Wei, X.-H., Ding, H.-L., Lin, Z.-J., 湛海伦, Yang, F., Li, W.-B., Xie, J.-C., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12072282
Sex-biased toll-like receptor 4 signaling in nociplastic pelvic pain
Lenert, M. E., Pontari, M. A., Hildago-Lopez, E., Clemens, J. Q., Kaplan, C. M., Harte, S. E., & Schrepf, A. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.107032
Metadata
- Authors
- Clauw, D. J., Schmidt, M., Radulovic, D., Singer, A., Katz, P., & Bresette, J.
- Affiliations
- Georgetown University Medical Center (US)
- Corresponding author
- Clauw, Daniel J.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 1997-01
- Volume
- 31
- Issue
- 1
- Pages
- 125-131
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2075137723
- Cited by
- 230
- References
- 16
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 14 · 2014: 15 · 2013: 9 · 2012: 16
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Psychiatric Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk049515-03)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK 49515-02)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- fibromyalgia, interstitial cystitis, chronic fatigue syndrome, symptom overlap, peripheral nociception, pain sensitivity, tender points, bladder pain, pelvic pain, urinary urgency and frequency, irritable bowel syndrome, headache, central sensitization
- MeSH terms
- Adult, Female, Fibromyalgia, Humans, Male, Middle Aged, Nociceptors, Pain Measurement, Cystitis, Interstitial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
