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Impact of major depression on chronic medical illness
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“Depression and anxiety are more prevalent in people with long-term physical condition(s) and more than seven times more common in those with two or more chronic physical conditions [6].”
From Can support workers from AgeUK deliver an intervention to support older people with anxiety and depression? A qualitative evaluation (2019) · cites this paper as [6]
In the citing paper
“MDD is also associated with elevated risk of onset, persistence, and severity of a wide range of chronic physical disorders as well as with increased early mortality due to an even wider range of physical disorders and to suicide.”
From The Costs of Depression (2012) · cites this paper as [106]
In the citing paper
“MDD is associated with significantly elevated risk of early death.104, 106, 119 This is true partly because people with MDD have high suicide risk,120–122 but also because depression is associated with elevated risk of the many types of disorders noted above. MDD is also associated with elevated mortality risk among people with certain kinds of disorders as part of a larger pattern of associations”
From The Costs of Depression (2012) · cites this paper as [106]
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“It is important to note that non-recognition of psychiatric comorbiditymay compromise adherence to treatment, increase functional impairment and worsen the prognosis of a patient with a chronic illness [37].”
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“The intervention is a web-based psychological treatment called Deprexis, which has been evaluated in previous trials [8] ([http://www.”
BackgroundMethodMajor depression in hospitalized Argentine general medical patients: Prevalence and risk factors
de la Torre, A. Y., Oliva, N., Echevarrieta, P. L., Pérez, B. G., Caporusso, G. B., Titaro, A. J., Kicyla, A. T., Cuatz, M., Locatelli, M., Nelson, L. M., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.066 · Cited by 22
“The presence of depression is reported to worsen medical prognosis, increase symptom burden, complicate self-care and treatment-adherence, increase length of hospitalization and the costs of care, and probably also increases mortality (Katon and Ciechanowski, 2002; Katon, 2011; Olver and Hopwood, 2013).”
BackgroundVIALLE, E. N., Pinto, B. M. D. O., Vialle, L. R., & Gomez, J. D. C. (2015) · European Journal of Orthopaedic Surgery & Traumatology · doi:10.1007/s00590-015-1641-2 · Cited by 22
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Red and White Meat Intake in Relation to Mental Disorders in Iranian Adults
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Loss of interest, depressed mood and impact on the quality of life: Cross-sectional survey
Guajardo, V. D., de Souza, B. P. F., Henriques, S. G., Lucia, M. C., Menezes, P. R., Martins, M. A., Tardivo, L. S. D. L. P. C., Gattaz, W. F., & Fráguas, R. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-826 · Cited by 21
Rachdi, C., Damak, R., Fekih Romdhane, F., Ouertani, H., & Cheour, M. (2019) · Primary Care Diabetes · doi:10.1016/j.pcd.2018.09.003 · Cited by 20
Fusing location data for depression prediction
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Relationship between obesity and depression in Korean adults
Hong, S. M., & Hur, Y. (2017) · Medicine · doi:10.1097/md.0000000000009478 · Cited by 20
Rosenthal, L. J. (2017) · Psychiatric Annals · doi:10.3928/00485713-20170601-02 · Cited by 20
Asdaq, S. M. B., & Yasmin, F. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.05.086 · Cited by 19
Prevention of depression in chronically physically ill adults
Kampling, H., Baumeister, H., Jäckel, W. H., & Mittag, O. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011246 · Cited by 20
Weiterbildung CME: Angst und Depression bei körperlicher Erkrankung
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Mental health and sense of coherence among Swedish adults with cystic fibrosis
Brucefors, A. B., Hjelte, L., & Hochwälder, J. (2010) · Scandinavian Journal of Caring Sciences · doi:10.1111/j.1471-6712.2010.00840.x · Cited by 19
Depressive Störungen bei körperlich Kranken
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Exploring Treatment for Depression in Parkinson’s Patients: A Cross-Sectional Analysis
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Towards the Psychosocial Treatment of Depressed Patients on Dialysis
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Alamri, A. S., Alhomrani, M., Alsanie, W. F., Almuqbil, M. S., Alqarni, K. M., Alshehri, S. M., Abdulaziz, O., Salih, M. M., Raafat, B. M., Alamri, A., et al. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.999813 · Cited by 17
“In the literature, there is a well-established link between depression and several chronic conditions (33).”
BackgroundUrban-rural and gender differential in depressive symptoms among elderly in India
Kumar, S., Chauhan, S., Patel, R., Kumar, M., & Simon, D. J. (2023) · Dialogues in Health · doi:10.1016/j.dialog.2023.100114 · Cited by 18
“However, impact of major depression are also said to affect chronic medical illness [22].”
BackgroundThe patients‘ perspective - a qualitative analysis of experiencing a fracture-related infection
Wimalan, B., Rupp, M., Alt, V., & Walter, N. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1126826 · Cited by 17
“In addition, it is well-known that depression in patients with chronic medical illness enhances symptom burden which leads to additive function impairment (Katon and Ciechanowski, 2002; Iakovou and Schulpis, 2019).”
BackgroundNinou, A., Guthrie, E., Paika, V., Ntountoulaki, E., Tomenson, B., Tatsioni, A., Karagiannopoulou, E., Carvalho, A. F., & Hyphantis, T. N. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.01.001 · Cited by 17
“Evidence suggests that a quarter of people with LTCs have comorbid mental disorders [8,9], which lead to negative outcomes [10], and increased medical costs [11] and more frequent use of the accident and emergency department (AED) [12].”
BackgroundThe Intersection of Mental and Physical Health in Older Mexican Americans
Schneider, M. G. (2004) · Hispanic Journal of Behavioral Sciences · doi:10.1177/0739986304267204 · Cited by 17
THE RELATIONSHIPS AMONG HEALTH FUNCTIONING INDICATORS AND DEPRESSION IN OLDER ADULTS WITH DIABETES
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Psychological Distress Among Older Prisoners: A Literature Review
Baidawi, S., & Trotter, C. (2015) · Journal of Forensic Social Work · doi:10.1080/1936928x.2015.1075166 · Cited by 18
“…symptoms should be considered a public health issue among ageing populations given their association with physical morbidity and mortality (Katon & Ciechanowski, 2002), decreased physical functioning (Stuck et al., 1999), high health service utilization (Katon & Ciechanowski, 2002; Luber…”
BackgroundThe relationship among depressive symptoms and chronic diseases in the elderly
Lim, J.-H. (2014) · Journal of Digital Convergence · doi:10.14400/jdc.2014.12.6.481 · Cited by 15
Davison, A. S., Harrold, J. A., Hughes, G., Norman, B. P., Devine, J., Usher, J. L., Hughes, A. T., Khedr, M., Gallagher, J. A., Milan, A. M., et al. (2018) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2018.07.008 · Cited by 15
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“Hence, although social experiences may have the most robust effects on mental health, they also clearly have the potential to “get under the skin” and are related to physical health outcomes and even mortality (Aneshensel et al. 1984; Hayward and Gorman 2004; Katon and Ciechanowski 2002; Taylor et al. 1997).”
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“Depression is a prevalent mental health problem that impacts the overall health of an individual, and incurs higher medical costs and mortality (Cuijpers & Smit, 2002; Katon & Ciechanowski, 2002; Simon, 2003).”
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“Depression is associated with adverse health outcomes in patients with chronic medical conditions [1].”
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“Comorbid physical health and psychiatric diagnoses are further associated with decreased treatment adherence and coping ability, often leading to amplification of symptom severity and functional impairment (Katon & Ciechanowski, 2002).”
BackgroundSerum Vitamin D and Depressive Symptomatology among Boston-Area Puerto Ricans
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“Suffering from ≥1 chronic diseases can increase the risk of developing depression, and depression itself can contribute to poor physical health (93).”
BackgroundAt the Heart of Resilience: Empowering Women’s Agency in Navigating Cardiovascular Disease
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“76,77 This correlation between chronic medical conditions and heightened psychiatric risk is further emphasized by the speci fi c case of posttraumatic stress disorder (PTSD), in which sufferers experience a markedly increased risk of cardiac incidents and mortality, distinct from the in fl uence of…”
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Depression bei körperlichen Erkrankungen
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Improving quality of care for mental illness in an uninsured, low-income primary care population
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“People with untreated mental illness are less likely to maintain a healthy lifestyle [11,12], adhere to self-care regimens for concurrent medical illnesses [13–15] and are at increased risk for developing chronic medical illness [11,12].”
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Prevalência e relação de fatores emocionais e clínicos em pacientes com discopatia degenerativa
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Psychological Problems in Breast Cancer Patients: A Review
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“Numerous studies have demonstrated that the prevalence of anxiety and depressive disorders is higher among IBD patients compared to the general population and other chronic diseases (Robertson et al., 1989; Addolorato et al., 1997; Katon and Ciechanowski, 2002; Katon et al., 2007; Kovács and Kovács, 2007; Scott et al.…”
BackgroundPartners’ Experiences of Chronic Pain: A Qualitative Evidence Synthesis
Borthwick, C., Penlington, C., & Robinson, L. J. (2024) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-024-10012-w · Cited by 7
“This can create a vicious cycle, as the presence of depression and unhelp-ful thought patterns such as catastrophising are associated with greater pain intensity and disability (Bair et al., 2003; Driscoll et al., 2021; Katon & Ciechanowski, 2002).”
Challenging Normative Orthodoxies in Depression: Huxley's Utopia or Dante's Inferno?
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Robinson, M. A., Kim, I., Mowbray, O. P., & Disney, L. (2021) · Community Mental Health Journal · doi:10.1007/s10597-021-00833-6 · Cited by 8
Psychische Störungen bei somatischen Krankheiten
Kapfhammer, H. P. (2011) · Springer eBooks · doi:10.1007/978-3-642-03637-8_76 · Cited by 7
Picardi, A., Adler, D. A., Chang, H., Lega, I., Gigantesco, A., Pasquini, P., Matteucci, G., Zerella, M. P., Caredda, M., Tarsitani, L., et al. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04022.x · Cited by 7
Symptoms of depression among adults in rural areas of western Poland
Łojko, D., Czajkowska, A., Suwalska, A., Pałys, W., Jaracz, K., Górna, K., Pniewska, J., Gołębiewska, K., Baron, U., & RYBAKOWSKI, J. K. (2015) · Annals of Agricultural and Environmental Medicine · doi:10.5604/12321966.1141386 · Cited by 7
“On the other hand, somatic disorders might worsen the clinical course of depression and precipitate the occurrence of mood disorders [13, 14, 15].”
BackgroundDepression associated with chronic illness
McLachlan, E. (2011) · InnovAiT Education and inspiration for general practice · doi:10.1093/innovait/inr013 · Cited by 7
Screening Medical Patients for Depression: Lessons From a National Program in Cancer Clinics
Walker, J., Wanat, M., Fielding, J., Martin, P., Petit, A., Burke, K., & Sharpe, M. (2017) · Psychosomatics · doi:10.1016/j.psym.2017.01.002 · Cited by 7
Chew-Graham, C. A., Shepherd, T. A., Burroughs, H., Dixon, K., & Kessler, D. S. (2018) · BMC Family Practice · doi:10.1186/s12875-018-0877-4 · Cited by 7
“Currently, depression is thought to affect approximately one in ten of the population [2] and the prevalence of depressive symptoms may increase with age [3] Depression is more common in those people with long-term physical conditions [4].”
BackgroundPsychiatric symptoms among patients with acute abdominal pain
Lexne, E., Brudin, L. H., Marteinsdóttir, Í., Strain, J. J., & Nylander, P. (2020) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2020.1782464 · Cited by 7
Wong, J. J., Maddux, M. H., & Park, K. T. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001947 · Cited by 7
“Left untreated, comorbid depression interferes with IBD treatment adherence (8,13) and can lead to smoking, poor diet, overeating, sedentary lifestyle, and other undesirable health outcomes reaching into adulthood (14,15).”
BackgroundRheumatoid Arthritis: A Historical and Biopsychosocial Perspective
Zyrianova, Y. (2012) · InTech eBooks · doi:10.5772/26138 · Cited by 7
Stewart, D. E. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.080126 · Cited by 7
Psychische Störungen bei somatischen Krankheiten
Kapfhammer, H. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_88 · Cited by 6
Metadata
- Authors
- Katon, W., & Ciechanowski, P.
- Affiliations
- University of Washington (US)
- Corresponding author
- Katon, Wayne
- ORCID
- Ciechanowski, Paul
- Venue
- Journal of Psychosomatic Research
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 53
- Issue
- 4
- Pages
- 859-863
- ISSN
- 0022-3999 (ISSN-L)
- OpenAlex
- W2046779437
- Cited by
- 485
- References
- 61
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 20 · 2023: 16 · 2022: 11 · 2021: 24 · 2020: 20 · 2019: 21 · 2018: 14 · 2017: 29 · 2016: 27 · 2015: 27 · 2014: 34 · 2013: 30 · 2012: 27
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychosomatic Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH0-11643, MH4-1739)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- major depressive disorder, chronic disease, cognitive behavioral therapy, depression relapse prevention, depression recurrence, antidepressants, follow-up duration
- MeSH terms
- Aging, Chronic Disease, Depressive Disorder, Diabetes Mellitus, Heart Diseases, Humans, Self Care, United States, Comorbidity
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