The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hypoxia-like tissue injury as a component of multiple sclerosis lesions
Open accessAbstract
Recent data suggest that the mechanisms of demyelination and tissue damage in multiple sclerosis (MS) are heterogenous. In this review, evidence is discussed, which show that in a subset of multiple sclerosis patients the central nervous system (CNS) lesions show profound similarities to tissue alterations found in acute white matter stroke, thus suggesting that a hypoxia-like metabolic injury is a pathogenetic component in a subset of inflammatory brain lesions. Both, vascular pathology as well as metabolic disturbances induced by toxins of activated macrophages and microglia may be responsible for such lesions in multiple sclerosis.
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Citations
Cites
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Perivascular iron deposition and other vascular damage in multiple sclerosis.
Adams, C. W. (1988) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.2.260 · Cited by 178
Cited by
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724
Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis
Trapp, B. D., & Stys, P. K. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70043-2 · Cited by 621
Krumbholz, M., Theil, D., Cepok, S., Hemmer, B., Kivisäkk, P., Ransohoff, R. M., Hofbauer, M., Farina, C., Derfuss, T., Hartle, C., et al. (2006) · Brain · doi:10.1093/brain/awh680 · Cited by 561
Law, M., Saindane, A. M., Ge, Y., Babb, J. S., Johnson, G., Mannon, L. J., Herbert, J., & Grossman, R. I. (2004) · Radiology · doi:10.1148/radiol.2313030996 · Cited by 242
Mháille, A. N., McQuaid, S., Windebank, A., Cunnea, P., McMahon, J., Samali, A., & FitzGerald, U. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318165b239 · Cited by 128
Metadata
- Authors
- Lassmann, H.
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 206
- Issue
- 2
- Pages
- 187-191
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2067200113
- Cited by
- 218
- References
- 3
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lassmann, H. (2003). Hypoxia-like tissue injury as a component of multiple sclerosis lesions. Journal of the Neurological Sciences. https://doi.org/10.1016/s0022-510x(02)00421-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
