The DOI matches its Crossref record; 36 of the 38 references it cites were found in a registry or an index.
On the origin of the transfer RNA molecule
Abstract
Data and arguments are given in favour of the hypothesis that the primitive tRNA molecule may have originated from a direct duplication event involving one of the two halves of the tRNA molecule. It seems that a molecule capable of assuming a hairpin structure was involved as a precursor in this duplication. The two halves of the present tRNAs could, therefore, be considered as paralogous.
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“Among the 20 amino acids in the universal code, approximately half came from the prebiotic soup; as we see in the SNS code, the remaining half of amino acids were derivatives of the first set of 10 primitive amino acids by biosynthesis [78].”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [78]
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Rodin, A. S., Szathmáry, E., & Rodin, S. N. (2011) · Biology Direct · doi:10.1186/1745-6150-6-14 · Cited by 98
Metadata
- Authors
- Giulio, M. D.
- Affiliations
- Institute of Genetics and Biophysics (IT)
- Corresponding author
- Giulio, Massimo Di
- ORCID
- Giulio, Massimo Di
- Venue
- Journal of Theoretical Biology
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 159
- Issue
- 2
- Pages
- 199-214
- ISSN
- 0022-5193 (ISSN-L)
- OpenAlex
- W1968532770
- Cited by
- 131
- References
- 38
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 11 · 2014: 5 · 2013: 6 · 2012: 7
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Theoretical Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- tRNA, molecular evolution, gene duplication, hairpin structure, paralogs, tRNA structure
- MeSH terms
- Amino Acid Sequence, Animals, Biological Evolution, Models, Genetic, Molecular Sequence Data, RNA, Transfer, Sequence Homology
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