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The Efficacy of Fluoxetine in the Treatment of Premature Ejaculation: A Double-Blind Placebo Controlled Study
Abstract
PURPOSE: The efficacy of the selective serotonin re-uptake inhibitor fluoxetine in the treatment of premature ejaculation was examined. MATERIALS AND METHODS: The study comprised 17 patients with premature ejaculation who presented to the urology clinic of our medical school. In this double-blind study the patients were randomized into treatment groups receiving 20 mg. fluoxetine daily for 1 week and 40 mg. daily afterward (group 1) or 1 capsule placebo daily for 1 week and 2 capsules daily afterward (group 2). The groups were evaluated according to the latent period of intravaginal ejaculation. RESULTS: The latent period of intravaginal ejaculation in group 1 was significantly longer than that in group 2. Nausea, headache and insomnia were reported side effects. CONCLUSIONS: Fluoxetine may be regarded as a safe and effective alternative in the treatment of premature ejaculation.
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Citations
Cited by
Disorders of Orgasm and Ejaculation in Men
Rowland, D., McMahon, C. G., Abdo, C., Chen, J., Jannini, E., Waldinger, M. D., & Ahn, T. Y. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01782.x · Cited by 508
Althof, S. E., McMahon, C. G., Waldinger, M. D., Serefoglu, E. C., Shindel, A. W., Adaikan, P. G., Becher, E., Dean, J., Giuliano, F., Hellstrom, W. J. G., et al. (2014) · Sexual Medicine · doi:10.1002/sm2.28 · Cited by 444
Althof, S. E., Abdo, C. H. N., Dean, J., Hackett, G., McCabe, M., McMahon, C. G., Rosen, R. C., Sadovsky, R., Waldinger, M., Becher, E., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01975.x · Cited by 403
AUA GUIDELINE ON THE PHARMACOLOGIC MANAGEMENT OF PREMATURE EJACULATION
MONTAGUE, D. K., JAROW, J., BRODERICK, G. A., DMOCHOWSKI, R. R., HEATON, J. P. W., LUE, T. F., NEHRA, A., SHARLIP, I. D., & PANEL, O. T. A. E. D. G. U. (2004) · Journal of Urology · doi:10.1097/01.ju.0000132159.61156.ea · Cited by 291
Althof, S. E., McMahon, C. G., Waldinger, M. D., Serefoglu, E. C., Shindel, A. W., Ganesan Adaikan, P., Becher, E., Dean, J., Giuliano, F., Hellstrom, W. J. G., et al. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12504 · Cited by 281
Metadata
- Authors
- Kara, H., Aydin, S., Agargun, M. Y., Odabas, O., & Yilmaz, Y.
- Venue
- Journal of Urology
- Published
- 1996-11
- Volume
- 156
- Issue
- 5
- Pages
- 1631-1632
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- OpenAlex
- W2000640050
- Cited by
- 187
- References
- 0
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Efficacy of Fluoxetine in the Treatment of Premature Ejaculation: A Double-Blind Placebo Controlled Study. https://app.cochat.ai/papers/10.1016/s0022-5347(01)65467-3
- The paper
- Kara, H., Aydin, S., Agargun, M. Y., Odabas, O., & Yilmaz, Y. (1996). The Efficacy of Fluoxetine in the Treatment of Premature Ejaculation: A Double-Blind Placebo Controlled Study. Journal of Urology. https://doi.org/10.1016/s0022-5347(01)65467-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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