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Cited by 30Pediatric Urology and Nephrology StudiesKidney Stones and Urolithiasis TreatmentsUrological Disorders and Treatments

The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.

Renal Tubular Abnormalities in Infants with Hydronephrosis

Chandar, Jayanthi, Abitbol, Carolyn, Zilleruelo, Gaston, Gosalbez, Rafael, Montane, Brenda, Strauss, Jose·1996·Journal of Urology
DOI 10.1016/s0022-5347(01)66492-9
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Abstract

PURPOSE: Abnormalities in renal tubular function have been observed in hydronephrotic urinary tract disease, resulting in metabolic acidosis, hyperkalemia and excessive free water diuresis. The frequency of these abnormalities, particularly in our infant population, was the impetus for our study. MATERIALS AND METHODS: We studied 50 infants selected from 199 patients followed for hydronephrosis before any surgical intervention during a 5-year period. Mean patient age was 1.5 +/- 1.0 months at the time of diagnosis by ultrasound, voiding cystourethrography and a radionuclide renal scan. Lesions were classified as unilateral or bilateral and graded according to severity of renal pelvic dilatation or grade of vesicoureteral reflux. RESULTS: At least 1 abnormality of tubular function was present in 29 patients (58%) of whom the predominant abnormality was renal tubular acidosis in 23 (79%, 46% of the total study group). Renal tubular acidosis was diagnosed on the basis of a serum total carbon dioxide of 19 mM./l. or less with urinary pH 5.5 or greater. The defect appeared to be distal in most cases. Other abnormalities included defects in urinary concentrating ability in 10 patients (4 with unilateral urinary tract dilatation). Distal tubular aldosterone resistance in 6 patients (3 with unilateral dilatation) was demonstrated by hyperkalemia with a low transtubular potassium gradient of 3 or less and low fractional excretion of potassium. Although common in unilateral lesions, renal tubular dysfunction became more prevalent with an increase in severity score and bilaterality. CONCLUSIONS: Renal tubular dysfunction is frequent in hydronephrotic infants with unilateral or bilateral disease. Although rarely life threatening and usually self-limiting, the metabolic consequences of these abnormalities require investigation to allow for appropriate medical management.

Overview

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Registry

Crossref · 10.1016/s0022-5347(01)66492-9

Cites

18 of 18 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Chandar, J., Abitbol, C., Zilleruelo, G., Gosalbez, R., Montane, B., & Strauss, J.
Affiliations
  • University of Miami (US)
  • Departments of Pediatrics and Urology, University of Miami, Jackson Memorial Medical Center, Miami, Florida.
ORCID
Venue
Journal of Urology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1996-02
Volume
155
Issue
2
Pages
660-663
ISSN
  • 0022-5347 (ISSN-L)
  • 1527-3792
DOI
10.1016/s0022-5347(01)66492-9
OpenAlex
W1967524324
Cited by
30
References
19
Citations by year
2025: 1 · 2024: 1 · 2021: 1 · 2017: 1 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
1.39
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Urology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Urology and Nephrology Studies
  • Health Sciences › Medicine › Urology › Kidney Stones and Urolithiasis Treatments
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords
hydronephrosis, renal tubular dysfunction, infants, renal tubular acidosis, hyperkalemia, aldosterone resistance, urinary concentrating defect, vesicoureteral reflux, renal pelvic dilatation, metabolic acidosis
MeSH terms
Female, Follow-Up Studies, Humans, Hydronephrosis, Infant, Infant, Newborn, Male, Retrospective Studies, Severity of Illness Index, Urinary Tract Infections, Renal Tubular Transport, Inborn Errors, Prevalence

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.