The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
HYPOSPADIAS AND URETHRAL DEVELOPMENT
Abstract
PURPOSE: Hypospadias is a common congenital anomaly that may be treated with surgical reconstruction. In the majority of cases the etiology remains elusive. Although androgens are clearly critical for penile development, defects in androgen metabolism and/or the androgen receptor explain only a small subset of cases of hypospadias. Strategies are presented for understanding the etiology of hypospadias. MATERIALS AND METHODS: Current scientific reports on the etiology of hypospadias were reviewed, and the embryology and possible mechanisms of urethral and penile formation are presented. RESULTS: A new theory of glandular human urethral development via endodermal cellular differentiation is proposed to replace the classic explanation of ectodermal intrusion. CONCLUSIONS: Careful studies of penile and urethral development have led to a better understanding of genital embryology. Future areas of study, such as endocrine disrupters, mesenchymal-epithelial interactions and mechanisms of penile growth, are proposed to explain the etiology of hypospadias.
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Cites
Steroid 5α-Reductase 2 Deficiency*
WILSON, J. D., GRIFFIN, J. E., & RUSSELL, D. W. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-5-577 · Cited by 346
Cited by
Hypospadias, all there is to know
van der Horst, H. J. R., & de Wall, L. L. (2017) · European Journal of Pediatrics · doi:10.1007/s00431-017-2864-5 · Cited by 308
Kim, K., Liu, W., Cunha, G. R., Russell, D. W., Huang, H., Shapiro, E., & Baskin, L. S. (2002) · Cell and Tissue Research · doi:10.1007/s004410100464 · Cited by 118
Self-citationLi, Y., Sinclair, A., Cao, M., Shen, J., Choudhry, S., Botta, S., Cunha, G., & Baskin, L. (2015) · Journal of Urology · doi:10.1016/j.juro.2014.09.108 · Cited by 97
Liu, X., Liu, S., Fan, Y., Qi, J., Wang, X., Bai, W., Chen, D., Xiong, C., & Zhang, L. (2021) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2021.08.014 · Cited by 13
Liu, X., Liu, S., Feng, S., Wang, X., Bai, W., Xiao, J., Chen, D., Xiong, C., & Zhang, L. (2021) · Journal of Polymer Research · doi:10.1007/s10965-021-02802-9 · Cited by 11
Metadata
- Authors
- Baskin, L. S.
- Venue
- Journal of Urology
- Published
- 2000-03
- Volume
- 163
- Issue
- 3
- Pages
- 951-956
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- OpenAlex
- W2026593665
- Cited by
- 293
- References
- 1
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Baskin, L. S. (2000). HYPOSPADIAS AND URETHRAL DEVELOPMENT. Journal of Urology. https://doi.org/10.1016/s0022-5347(05)67861-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
