Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats
Abstract
We have investigated the biological effects of physiological doses of 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) (at doses from 2.5 to 10 microg/100 g BW) on serum TSH and GH levels in rats made hypothyroid by propylthiouracil and iopanoic acid administration. In such animals deiodinase activities were inhibited and thyroid hormones serum levels strongly reduced. The effects of T2s were compared with those elicited by 3,5,3'-triiodo-L-thyronine (T3) (2.5 microg/100 g BW).The serum TSH level was much greater in hypothyroid rats than in euthyroid ones. T3 administration suppressed TSH by 88% compared to control (i.e, the level in hypothyroid rats); it thus reached a value not significantly different from that seen in the euthyroid rats. 3,5-T2 produced a similar effect, suppressing the TSH level by about 75% compared to control; it thus reached values not significantly different from those of the euthyroid and T3-treated rats. By contrast, 3,3'-T2 had no effect on TSH, whatever the dose. The serum GH level was much lower in hypothyroid rats than in euthyroid ones. T3 administration increased the GH level by about 5-fold, restoring it to the value seen in euthyroid rats. 3,5-T2-treated hypothyroid rats, at all the doses used (from 2.5 to 10 microg/100 g BW), showed increased serum GH levels: at a dose of 10 microg/100 g BW the level reached a value about 5-fold higher than that in hypothyroid rats. This value was not significantly different from those…
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3,5-T2 decreases TSH levels in hypothyroid rats.
“and it was also able to decrease the TSH levels of hypothyroid rats (Moreno et al. 1998).”
From Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues (2014) · cites this paper as Moreno et al. 1998
3,5-T2 by itself might exert negative feedback on TSH.
“demonstrating that 3,5-T2 by itself might be exerting the negative feedback, as suggested previously (Horst et al. 1995, Moreno et al. 1998).”
From Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues (2014) · cites this paper as Moreno et al. 1998
The chronic effects of 3,5-T2 on proteins involved in thyroid hormone biosynthesis and thyroid hormone metabolism had not been assessed before this study.
“Despite the possible interference of 3,5-T2 on thyroid function (Horst et al. 1995, Baur et al. 1997, Moreno et al. 1998, García-G et al. 2007), to our knowledge, the chronic effects of 3,5-T2 on proteins involved in thyroid hormone biosynthesis (Kopp 2013) and thyroid hormone metabolism have not been assessed thus far.”
From Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues (2014) · cites this paper as Moreno et al. 1998
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Padron, A. S., Neto, R. A. L., Pantaleão, T. U., de Souza dos Santos, M. C., Araujo, R. L., de Andrade, B. M., da Silva Leandro, M., de Castro, J. P. S. W., Ferreira, A. C. F., & de Carvalho, D. P. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0502 · Cited by 69 · see citing works
- Authors
- Moreno, M., Lombardi, A., Lombardi, P., Goglia, F., & Lanni, A.
- Affiliations
- University of Naples Federico II (IT)
- Corresponding author
- Lanni, Antonia
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 62
- Issue
- 26
- Pages
- 2369-2377
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2061301495
- Cited by
- 21
- References
- 0
- Citations by year
- 2017: 3 · 2016: 1 · 2014: 4 · 2013: 3
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Funders
- European Commission
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- 3,5-diiodo-L-thyronine, triiodothyronine, thyroid-stimulating hormone, growth hormone, hypothyroidism, propylthiouracil, iopanoic acid, thyroid hormone replacement, TSH suppression
- MeSH terms
- Animals, Basal Metabolism, Diiodothyronines, Hypothyroidism, Iodide Peroxidase, Iopanoic Acid, Male, Propylthiouracil, Growth Hormone, Antithyroid Agents, Thyrotropin, Rats, Wistar, Rats
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