Neuroactive steroids alter the Crcadian system of the Syrian hamster in a phase-dependent manner
Abstract
Several steroid compounds affect neuronal function, primarily by modulating the GABAA receptor complex. A circadian variation in the brain concentration of neurosteroids has been reported in rats and humans. We have previously reported that natural occurring or synthetic neuroactive steroids such as androsterone and alphaxalone also have a rhythmic effect on behavior (anesthetic and anticonvulsant activity) and GABAergic activity. In the present work, we have tested the ability of neuroactive steroids to phase shift circadian rhythms in hamsters. The GABA(A) negative modulator dehydroepiandrosterone sulphate (DHEAS) elicited phase advances when administered at CT 6, while the positive modulator androsterone lacked any effect at this time. A complete phase response curve for DHEAS revealed a nonphotic-like effect. DHEAS also blocked the circadian effects of light, while androsterone induced photic-like responses. There is also evidence that neurosteroids may be present and even synthesized in the SCN. Collectively, the results so far indicate that some neuroactive steroids might modulate the activity of the circadian clock.
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In adult laboratory rodents, a wide variety of gonadal hormones can affect the phase of circadian rhythms.
“Indeed, in adult laboratory rodents a wide variety of gonadal hormones can affect the phase of circadian rhythms, including estrogens, progestins, androgens, and non-traditional neuroactive steroids (e.g., rats: [8, 17], hamsters: [49, 51, 129], mice: [23, 47, 78, 90], degus: [80, 100]).”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [51]
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Adolescent changes in the homeostatic and circadian regulation of sleep
Hagenauer, M. H., Perryman, J. I., Lee, T. M., & Carskadon, M. A. (2009) · Developmental Neuroscience · doi:10.1159/000216538 · Cited by 593 · see citing works
The neuroendocrine control of the circadian system: Adolescent chronotype
Hagenauer, M. H., & Lee, T. M. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.04.003 · Cited by 143 · see citing works
Hagenauer, M. H., Ku, J. H., & Lee, T. M. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.02.004 · Cited by 41 · see citing works
- Authors
- de Tezanos Pinto, F., & Golombek, D. A.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Golombek, Diego A.
- ORCID
- Golombek, Diego A.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 65
- Issue
- 23
- Pages
- 2497-2504
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2029938286
- Cited by
- 15
- References
- 0
- Citations by year
- 2026: 1 · 2022: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2012: 2
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neurosteroids, circadian rhythm, phase shift, golden hamster, dehydroepiandrosterone sulfate, androsterone, alfaxalone, GABAA receptor, suprachiasmatic nucleus, light entrainment, non-photic entrainment, circadian clock
- MeSH terms
- Androsterone, Animals, Circadian Rhythm, Cricetinae, Light, Male, Mesocricetus, Motor Activity, Photic Stimulation, Receptors, GABA-A, Time Factors, GABA Modulators, Dehydroepiandrosterone Sulfate
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