Diabetic peripheral neuropathic pain: clinical and quality-of-life issues
Abstract
Diabetic peripheral neuropathy (DPN) is estimated to be present in 50% of people living with diabetes mellitus (DM). Comorbidities of DM, such as macrovascular and microvascular changes, also Interact with DPN and affect its course. In patients with DM, DPN Is the leading cause of foot ulcers, which in turn are a major cause of amputation in the United States. Although most patients with DPN do not have pain, approximately 11% of patients with DPN have chronic, painful symptoms that diminish quality of life, disrupt sleep, and can lead to depression. Despite the number of patients affected by DPN pain, little consensus exists about the pathophysiology, best diagnostic tools, and primary treatment choices. This article reviews the current knowledge about and presents recommendations for diagnostic assessment of DPN pain based on a review of the literature.
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Neuropathic chronic pain is associated with psychosocial distress, depression, and sleep problems.
“Chronic pain from neuropathy is associated with prevalent psychosocial distress, depression, and sleep disturbance (125,126).”
From Psychosocial care for people with diabetes: a position statement of the American Diabetes Association (2016) · cites this paper as [126]
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References 54 · Cited by 256
- Authors
- Argoff, C. E., Cole, B. E., Fishbain, D. A., & Irving, G. A.
- Affiliations
- North Shore University Hospital (US)
- University of Miami (US)
- University of Washington (US)
- Corresponding author
- Cole, B. Eliot
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 81
- Issue
- 4
- Pages
- S3-S11
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W2149813500
- Cited by
- 256
- References
- 54
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 20 · 2021: 13 · 2020: 13 · 2019: 13 · 2018: 11 · 2017: 8 · 2016: 13 · 2015: 17 · 2014: 20 · 2013: 13 · 2012: 14
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mayo Clinic Proceedings (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- diabetic peripheral neuropathy, neuropathic pain, diabetes mellitus, quality of life, foot ulcer, amputation, depression, sleep disruption, diagnostic assessment, pathophysiology, treatment guidelines
- MeSH terms
- Diabetic Neuropathies, Diagnosis, Differential, Humans, Pain, Quality of Life, United States, Prevalence, Practice Guidelines as Topic, Diabetic Foot
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