Effect of Ursodeoxycholic Acid on Serum Lipids of Patients With Primary Biliary Cirrhosis
Abstract
Objective To study the effects of ursodeoxycholic acid (UDCA) on lipid levels in patients with primary biliary cirrhosis (PBC). Design A randomized, placebo-controlled prospective trial of UDCA was conducted in 177 well-characterized patients with PBC. Material and methods The two treatment groups (placebo and UDCA) were matched at entry with respect to age, sex, histologic stage of PBC, biochemical values, and serum lipid levels. Serum cholesterol, high-density lipoprotein cholesterol, and triglyceride levels were measured at entry, 1 year, and 2 years. Results The decrease in total cholesterol level at 1 and 2 years in the UDCA-treated group was significant in comparison with that in the placebo group. Serum high-density lipoprotein cholesterol and triglyceride levels, however, were unchanged. No severe side effects from UDCA were noted. The changes in serum cholesterol levels at 2 years were directly and strongly correlated with changes in serum bilirubin concentrations (r = 0.70; P Conclusion The cholesterol-lowering effect of UDCA could be related to amelioration of the underlying liver disease or to a direct effect of the drug on the metabolism of cholesterol in patients with hypercholesterolemia.
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UDCA therapy does not improve fatigue, pruritus, associated bone disease, or autoimmune features found in association with PBC.
“However, UDCA therapy does not improve fatigue, pruritus, associated bone disease, or autoimmune features found in association with PBC.(69,89,153,154)”
From Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases (2019) · cites this paper as [153]
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Lindor, K. D., Gershwin, E. M., Poupon, R., Kaplan, M., Bergasa, N. V., & Heathcote, J. E. (2009) · Hepatology · doi:10.1002/hep.22906 · Cited by 1,099 · see citing works
Self-citationLindor, K. D., Bowlus, C. L., Boyer, J., Levy, C., & Mayo, M. (2019) · Hepatology · doi:10.1002/hep.30145 · Cited by 913 · see citing works
Self-citationCarey, E. J., Ali, A. H., & Lindor, K. D. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00154-3 · Cited by 735 · see citing works
Self-citationAllocca, M., Crosignani, A., Gritti, A., Ghilardi, G., Gobatti, D., Caruso, D., Zuin, M., Podda, M., & Battezzati, P. M. (2006) · Gut · doi:10.1136/gut.2005.079814 · Cited by 92 · see citing works
- Authors
- BALAN, V., DICKSON, E. R., JORGENSEN, R. A., & LINDOR, K. D.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- LINDOR, KEITH D.
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 1994-10
- Volume
- 69
- Issue
- 10
- Pages
- 923-929
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W2039248220
- Cited by
- 48
- References
- 0
- Citations by year
- 2024: 2 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2012: 4
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mayo Clinic Proceedings (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- ursodeoxycholic acid, primary biliary cirrhosis, serum lipids, hypercholesterolemia, total cholesterol, HDL cholesterol, triglycerides, serum bilirubin, cholesterol metabolism, bile acid therapy
- MeSH terms
- Adult, Bilirubin, Cholesterol, Chronic Disease, Female, Humans, Hypercholesterolemia, Cholesterol, HDL, Liver Cirrhosis, Biliary, Male, Middle Aged, Prospective Studies, Triglycerides, Ursodeoxycholic Acid
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