Magnesium-creatine supplementation effects on body water
Abstract
This study evaluated magnesium-creatine (MgCre) supplementation on body water and quadriceps torque. Maltodextran (Placebo), Mg oxide plus Cre (MgO-Cre), and Mg-creatine chelate (MgC-Cre) at 800 mg Mg and 5 g Cre per day were used for 2 weeks in 35 subjects in a random assignment, blinded study. Pre-post measures were completed with bioimpedance to determine total body water (TBW), extracellular water (ECF), and intracellular water (ICF), and an isokinetic device at 180 degrees per second for knee extension peak torque (T), total work (W), and power (PWR). Body weights increased for both treatment groups, MgO-Cre Delta 0.75 kg (P <.05) and MgC-Cre Delta 0.4 kg (P =.07). Significant pre-post differences (P <.05) were noted only for MgC-Cre in ICW (26.29 v 28.01 L) and ECW (15.75 v 14.88 L). MgC-Cre had significant peak T (Nm) increase (124.5 v135.8, P <.05), while MgO-Cre (116.4 v 124.9, P =.06) and placebo (119.8 v 123.7, P =.343) did not. Both treatment groups had increased PWR (P <.05). MgC-Cre affects cellular fluid compartments. The peak torque changes were significant only in the MgC-Cre group, which had increases in ICW that may infer more muscular creatine due to its osmotic effect, and with increased cellular hydration, perhaps increased protein synthesis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Body water increased with MgCr-C but not CrM, while torque and power increased similarly with CrM and MgCr-C.
“Results revealed that body water increased with MgCr-C, but not CrM while torque and power increased similarly with CrM and MgCr-C.”
From Bioavailability, Efficacy, Safety, and Regulatory Status of Creatine and Related Compounds: A Critical Review (2022) · cites this paper as [189]
Cites
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891 · see citing works
Greenhaff, P. L., Casey, A., Short, A. H., Harris, R., Soderlund, K., & Hultman, E. (1993) · Clinical Science · doi:10.1042/cs0840565 · Cited by 460 · see citing works
Effects of creatine supplementation on body composition, strength, and sprint performance
KREIDER, R. B., FERREIRA, M., WILSON, M., GRINDSTAFF, P., PLISK, S., REINARDY, J., CANTLER, E., & ALMADA, A. L. (1998) · Medicine &amp Science in Sports &amp Exercise · doi:10.1097/00005768-199801000-00011 · Cited by 430 · see citing works
Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina
Sipilä, I., Rapola, J., Simell, O., & Vannas, A. (1981) · New England Journal of Medicine · doi:10.1056/nejm198104093041503 · Cited by 181 · see citing works
Kraemer, W. J., & Volek, J. S. (1999) · Clinics in Sports Medicine · doi:10.1016/s0278-5919(05)70174-5 · Cited by 130 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kreider, R. B., Jäger, R., & Purpura, M. (2022) · Nutrients · doi:10.3390/nu14051035 · Cited by 103 · see citing works
Effect of Creatine Ingestion after Exercise on Muscle Thickness in Males and Females
CHILIBECK, P. D., STRIDE, D., FARTHING, J. P., & BURKE, D. G. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000142301.70419.c6 · Cited by 89 · see citing works
Fazio, C., Elder, C. L., & Harris, M. M. (2022) · Journal of Strength & Conditioning Research · doi:10.1519/jsc.0000000000003873 · Cited by 20 · see citing works
- Authors
- Brilla, L. R., Giroux, M. S., Taylor, A., & Knutzen, K. M.
- Affiliations
- Western Washington University (US)
- Corresponding author
- Brilla, L.R
- ORCID
- Brilla, L.R
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 52
- Issue
- 9
- Pages
- 1136-1140
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2035778870
- Cited by
- 22
- References
- 5
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2016: 3 · 2015: 1
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- creatine, magnesium oxide, total body water, extracellular water, intracellular water, quadriceps torque, knee extension, isokinetic strength, muscle power, cellular hydration, osmotic effects
- MeSH terms
- Adult, Body Water, Creatine, Diet, Double-Blind Method, Female, Humans, Magnesium, Male, Placebos, Weight Gain, Muscle, Skeletal, Torque, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
