Cochlear Dysfunction in Type 2 Diabetes: A complication Independent of Neuropathy and Acute Hyperglycemia
Abstract
The effects of type 2 diabetes on evoked otoacoustic emissions (e-OAEs) elicited by clicks in subjects with normal hearing and the involvement of the central (CNS) and peripheral nervous system and acute hyperglycemia were investigated. In study 1, 110 type 2 diabetic patients and 106 control subjects matched for age and gender were investigated by e-OAEs. Central and peripheral neuropathy were evaluated respectively by auditory brainstem responses (ABRs) and according to San Antonio Consensus Conference criteria. In study 2, 10 healthy and 10 type 2 diabetic men matched for age, all with normal e-OAEs, underwent a 5-hour hyperglycemic clamp study. e-OAE tests were performed before and during the hyperglycemic clamp. In study 1, e-OAEs were impaired in 51.8% (57 of 110) of the diabetic subjects, in comparison to 4.7% (five of 106) of the control group (P < .0001). Diabetics with impaired e-OAEs (e-OAEs-), in comparison to those with normal e-OAEs (e-OAEs+), were older (51.0+/-5.8 v 45.1+/-6.0 years, P < .001), had diabetes longer (11.5+/-4.4 v 7.0+/-3.9 years, P < .001), achieved poorer metabolic control as judged by hemoglobin A1c ([HbA1c] 6.9%+/-0.4% v 6.5%+/-0.3%, P < .001), and had more peripheral neuropathy (46% v 23%, P < .02). No difference was observed between e-OAEs- and e-OAEs+ subjects for retinopathy or nephropathy. Nevertheless, when the duration of diabetes was corrected by multiple regression analysis, the correlation between sensorineural damage and peripheral…
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One previous study found no difference in outer hair cell damage, represented by evoked otoacoustic emissions, between DM patients and healthy subjects in an acute hyperglycemic clamp study.
“one previous study [34] found no difference in the outer hair cell (OHC) damage, represented by evoked otoacoustic emissions (e-OAEs), between DM patients and healthy subjects in an acute hyperglycemic clamp study”
From Prognostic Factors Associated with Recovery from Recurrent Idiopathic Sudden Sensorineural Hearing Loss: Retrospective Analysis and Systematic Review (2022) · cites this paper as [34]
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- Authors
- Sasso, F. C., Salvatore, T., Tranchino, G., Cozzolino, D., Caruso, A. A., Persico, M., Gentile, S., Torella, D., & Torella, R.
- Affiliations
- University of Campania "Luigi Vanvitelli" (IT)
- ORCID
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 48
- Issue
- 11
- Pages
- 1346-1350
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W1976734399
- Cited by
- 76
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 9 · 2023: 7 · 2022: 10 · 2021: 12 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Funders
- Oklahoma Agricultural Experiment Station
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- type 2 diabetes, cochlear dysfunction, evoked otoacoustic emissions, diabetic peripheral neuropathy, hyperglycemia, auditory brainstem response, sensorineural hearing loss, hyperglycemic clamp, diabetes duration, metabolic control, HbA1c, diabetes complications, retinopathy, kidney disease, otoacoustic emissions
- MeSH terms
- Acute Disease, Adult, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Female, Glycated Hemoglobin, Humans, Hyperglycemia, Male, Middle Aged, Time Factors, Glucose Clamp Technique, Cochlear Diseases, Logistic Models, Case-Control Studies, Evoked Potentials, Auditory, Brain Stem
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