DNA Damage Induced by Temozolomide Signals to both ATM and ATR: Role of the Mismatch Repair System

The DNA damage response: putting checkpoints in perspective

Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966

Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625

Regulation of the G2/M transition by p53

Taylor, W. R., & Stark, G. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204252 · Cited by 1,584

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

Hirao, A., Kong, Y., Matsuoka, S., Wakeham, A. C., Ruland, J., Yoshida, H., Liu, D., Elledge, S. J., & Mak, T. W. (2000) · Science · doi:10.1126/science.287.5459.1824 · Cited by 1,311

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

Zhao, H., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4129-4139.2001 · Cited by 1,091

Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation

Bulavin, D. V., Saito, S., Hollander, M. C., Sakaguchi, K., Anderson, C. W., Appella, E., & Fornace, A. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6845 · Cited by 716

The cellular response to p53: the decision between life and death

Sionov, R. V., & Haupt, Y. (1999) · Oncogene · doi:10.1038/sj.onc.1203130 · Cited by 608

Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

Pegg, A. E., Dolan, M. E., & Moschel, R. C. (1995) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60879-x · Cited by 506

Abscopal Effect and Drug-Induced Xenogenization: A Strategic Alliance in Cancer Treatment?

Franzese, O., Torino, F., Giannetti, E., Cioccoloni, G., Aquino, A., Faraoni, I., Fuggetta, M. P., Vecchis, L. D., Giuliani, A., Kaina, B., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910672 · Cited by 12

Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma

André‐Grégoire, G., Maghe, C., Douanne, T., Rosińska, S., Spinelli, F. M., Thys, A., Trillet, K., Jacobs, K., Ballu, C., Dupont, A., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105118 · Cited by 18

Functional consequences of DNA mismatch repair missense mutations in murine models and their impact on cancer predisposition

Scherer, S. J., Avdievich, E., & Edelmann, W. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330689 · Cited by 12

Data-Driven Computational Modeling Identifies Determinants of Glioblastoma Response to SHP2 Inhibition

Day, E. K., Zhong, Q., Purow, B. W., & Lazzara, M. J. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-1756 · Cited by 10

Influence of Cell Cycle Checkpoints and p53 Function on the Toxicity of Temozolomide in Human Pancreatic Cancer Cells

Gupta, S., Sathishkumar, S., & Ahmed, M. M. (2010) · Pancreatology · doi:10.1159/000317254 · Cited by 10

Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival

Wilsker, D. F., Chung, J., Pradilla, I. F., Petermann, E., Helleday, T., & Bunz, F. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0675 · Cited by 10

Temozolomide does not influence the transcription or activity of matrix metalloproteinases 9 and 2 in glioma cell lines

Suzuki, Y., Fujioka, K., Ikeda, K., Murayama, Y., & Manome, Y. (2017) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2017.03.048 · Cited by 10

Probabilistic Modeling of DNA Mismatch Repair Effects on Cell Cycle Dynamics and Iododeoxyuridine-DNA Incorporation

Gürkan-Çavusoglu, E., Schupp, J. E., Aziz, M. A., Kinsella, T. J., & Loparo, K. A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0966 · Cited by 10

The effect of Msh2 knockdown on methylating agent induced toxicity in DNA glycosylase deficient cells

Cooley, N., Elder, R. H., & Povey, A. C. (2009) · Toxicology · doi:10.1016/j.tox.2009.12.008 · Cited by 8

Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation

Strath, J., Georgopoulos, L. J., Kellam, P., & Blair, G. E. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-67 · Cited by 7

Overexpression of PPM1B inhibited chemoresistance to temozolomide and proliferation in glioma cells

Yu, Y., Liu, Q., Ran, Q., & Cao, F. (2023) · Cell Biology International · doi:10.1002/cbin.12092 · Cited by 6

Cell state‐directed therapy – epigenetic modulation of gene transcription demonstrated with a quantitative systems pharmacology model of temozolomide

Saini, A., Ballesta, A., & Gallo, J. M. (2023) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12916 · Cited by 5

The Promise of Poly(ADP-Ribose) Polymerase (PARP) Inhibitors in Gliomas

Majd, N., Yap, T. A., Yung, W. K. A., & de Groot, J. (2020) · Journal of Immunotherapy and Precision Oncology · doi:10.36401/jipo-20-20 · Cited by 5

Involvement of mismatch repair proteins in adaptive responses induced by N-methyl-N′-nitro-N-nitrosoguanidine against γ-induced genotoxicity in human cells

Yamamoto, A., Sakamoto, Y., Masumura, K., Honma, M., & Nohmi, T. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.05.014 · Cited by 5

Biomass-derived carbon dots with pharmaceutical activity as temozolomide carrier for synergistic treatment of melanoma

Yang, Z., Yin, T., Wang, C.-Y., Zhu, G., Bai, L., Jiang, Z., & Zhang, W. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108919 · Cited by 4

Inhibition of DNA Repair as a Therapeutic Target

Veuger, S. J., & Curtin, N. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-396521-9.00008-5 · Cited by 4

Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates

Dillon, M. T., & Harrington, K. J. (2018) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-75836-7_5 · Cited by 3

Targeting DNA Repair Pathways for Cancer Therapy

Vens, C., & Sobol, R. W. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5847-0_6 · Cited by 2

Targeting DNA Damage Response Pathways in Cancer

Abdulrahman, G. O., & Curtin, N. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12394-7 · Cited by 2

GPI inactivation mediates pentose phosphate pathway flux switch-on inducing temozolomide resistance in glioma stem cell

Yin, J., Du, Z., Liu, X., Lu, C., Wang, X. H., Chen, Y., You, Y., Zhang, J., Ge, X., & Yan, W. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218384 · Cited by 1

Understanding signal transduction pathways to overcome targeted therapy resistance in glioblastoma

Tomiyama, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821567-8.00015-4 · Cited by 2

ATR as a Therapeutic Target

Middleton, F. K., & Curtin, N. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4741-2_10

Estudio de la función Dot1 en la respuesta celular al daño en el DNA en "Saccharomyces cerevisiae"

Pérez, F. M. C. (2009) · doi:10.14201/gredos.22497

Efeitos do Silenciamento de E2F1 e HEB, Fatores de Transcrição Preditos In Silico, em Células de Glioblastoma Irradiadas com Raios Gama.

Godoy, P. R. D. V. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2013.tde-13062013-094602

Targeting ATR for Cancer Therapy: Profile and Expectations for ATR Inhibitors

Curtin, N. J., & Pollard, J. R. (2018) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-75836-7_4

The Necroptosis Effector MLKL drives Small Extracellular Vesicle Release and Tumour Growth in GlioblastomaPreprint

André‐Grégoire, G., Douanne, T., Thys, A., Maghe, C., Jacobs, K., Ballu, C., Trillet, K., Busnelli, I., Hyenne, V., Goetz, J. G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.12.426398

Intratumoral heterogeneity associated with glioblastoma drug response and resistance

Salim, S. K., Savage, N. J., Maich, W. T., Venugopal, C., & Singh, S. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821567-8.00033-6

Sensitivity to temozolomide of cell lines derived from brain tumours and melanomas: relationship to MGMT gene expressionPreprint

Baguley, B. C., Joseph, W. R., Murray, P. M., Stowell, K. M., Leung, E. Y., & Marshall, E. S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.30.626133

Convergent adaptive architectures linking chemoresistance and radioresistance in chemoradiotherapy: a systems-level perspective

Yi, X., Song, F., Nagasawa, S., Imai, S., Arimatsu, H., Yamaoka, T., Shibata, K., Hayashida, R., Okuno, A., Urano, T., et al. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1813711

Defective DNA Mismatch Repair-dependent c-Abl-p73-GADD45α Expression Confers Cancer Chemoresistance

Li, L. S., Wagner, M. W., Meyers, M., & Boothman, D. A. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384999-1.10009-5

Contribution of ATM and ATR to the Resistance of Glioblastoma and Malignant Melanoma Cells to the Methylating Anticancer Drug Temozolomide

Eich, M., Roos, W. P., Nikolova, T., & Kaina, B. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0136 · Cited by 124

Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR–Chk1 pathway

Yamane, K., Taylor, K., & Kinsella, T. J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.030 · Cited by 48

CHK1 and CHK2 are differentially involved in mismatch repair–mediated 6-thioguanine-induced cell cycle checkpoint responses

Yan, T., Desai, A. B., Jacobberger, J. W., Sramkoski, R. M., Loh, T., & Kinsella, T. J. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1147.3.9 · Cited by 42

The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G 2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents

Hirose, Y., Katayama, M., Stokoe, D., Haas-Kogan, D. A., Berger, M. S., & Pieper, R. O. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8306-8315.2003 · Cited by 122

Early Chk1 Phosphorylation Is Driven by Temozolomide-Induced, DNA Double Strand Break- and Mismatch Repair-Independent DNA Damage

Ito, M., Ohba, S., Gaensler, K. M. L., Ronen, S. M., Mukherjee, J., & Pieper, R. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062351 · Cited by 31