The nonmutagenic repair of broken replication forks via recombination
Abstract
When replication forks stall or collapse at sites of DNA damage, there are two avenues for fork rescue. Mutagenic translesion synthesis by a special class of DNA polymerases can move a fork past the damage, but can leave behind mutations. The alternative nonmutagenic pathways for fork repair involve cellular recombination systems. In bacteria, nonmutagenic repair of replication forks may occur as often as once per cell per generation, and is the favored path for fork restoration under normal growth conditions. Replication fork repair is almost certainly the major function of bacterial recombination systems, and was probably the impetus for the evolution of recombination systems. Increasingly, the nonmutagenic repair of replication forks is seen as a major function of eukaryotic recombination systems as well.
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DSBs can be generated at stalled forks that contain strand termini of double-stranded/single-stranded DNA (ds-ssDNA) junctions, mostly from Okazaki fragments.
“DSBs can be generated at stalled forks [59,62-64] that contain strand termini of double-stranded/single-stranded DNA (ds-ssDNA) junctions, mostly from Okazaki fragments.”
From Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A (2009) · cites this paper as [62]
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References 121 · Cited by 112
- Authors
- Cox, M. M.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Cox, Michael M
- ORCID
- Cox, Michael M
- Venue
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 510
- Issue
- 1-2
- Pages
- 107-120
- ISSN
- 0027-5107 (ISSN-L)
- 1386-1964
- OpenAlex
- W1973720058
- Cited by
- 112
- References
- 121
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (GM32335, GM52725)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- replication fork repair, DNA recombination, translesion synthesis, DNA polymerase, mutagenesis
- MeSH terms
- Bacteria, DNA Damage, DNA Repair, DNA Replication, DNA Helicases, Humans, Models, Biological, Mutation, Recombination, Genetic
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