Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome
Abstract
Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus.
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Findings from mouse models of Down syndrome, particularly the Ts65Dn model, show reduced long-term potentiation and increased long-term depression, reflecting the relative strengthening and weakening, respectively, of individual synapses.
“This suggestion is largely driven by findings from mouse models of DS, particularly the Ts65Dn model, in which patch clamp electrophysiology analyses reveal reduced long-term potentiation (LTP) and increased long-term depression (LTD), reflecting the relative strengthening and weakening, respectively, of individual synapses123–126.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [124]
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References 13 · Cited by 184
- Authors
- Siarey, R. J., Carlson, E. J., Epstein, C. J., Balbo, A., Rapoport, S. I., & Galdzicki, Z.
- Affiliations
- National Institutes of Health (US)
- University of California, San Francisco (US)
- Corresponding author
- Galdzicki, Zygmunt
- ORCID
- Epstein, Charles J
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 38
- Issue
- 12
- Pages
- 1917-1920
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W1968536098
- Cited by
- 184
- References
- 13
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 10 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 11 · 2016: 11 · 2015: 5 · 2014: 12 · 2013: 8 · 2012: 15
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd031498-05)
- National Institute on Aging (AG-08938, P01AG008938)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-31498)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Ts65Dn mouse model, Down syndrome, synaptic depression, long-term depression, long-term potentiation, hippocampus, intellectual disability, field excitatory postsynaptic potentials, synaptic plasticity
- MeSH terms
- Animals, Disease Models, Animal, Down Syndrome, Hippocampus, Intellectual Disability, Long-Term Potentiation, Excitatory Postsynaptic Potentials, Mice
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