The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Randomized controlled trial of depot leuprolide in patients with chronic pelvic pain and clinically suspected endometriosis
Abstract
OBJECTIVE: To evaluate and compare the safety and efficacy of leuprolide versus placebo in managing chronic pelvic pain in women with clinically suspected endometriosis. METHODS: Women 18-45 years of age with moderate to severe pelvic pain of at least 6 months' duration underwent extensive, noninvasive diagnostic testing and laboratory evaluation, including pelvic ultrasound, complete blood count, determination of erythrocyte sedimentation rate, and endocervical cultures. Those with clinically suspected endometriosis were randomized to double-blind treatment for 3 months with depot leuprolide (3.75 mg/mo) or placebo. The accuracy of the clinical diagnosis of endometriosis was evaluated by posttreatment laparoscopy. RESULTS: Of 100 women randomized, 95 completed the study: 49 in the leuprolide group and 46 in the placebo group. Women in the leuprolide group had clinically and statistically significant (P < or = .001) mean improvements from baseline after 12 weeks of therapy in all pain measures. These mean improvements were significantly greater (P < or = .001) than those in the placebo group. At 12 weeks, mean decreases in physician-rated scores for dysmenorrhea, pelvic pain, and pelvic tenderness were 1.7, 1.0, and 0.8 points greater, respectively, in the leuprolide group than in the placebo group (on a four-point scale). Thirty-eight (78%) of 49 and 40 (87%) of 46 patients in the leuprolide and placebo groups, respectively, had laparoscopically confirmed endometriosis after 12 weeks of treatment. No women withdrew from the study because of adverse events. CONCLUSION: Depot leuprolide was effective and safe for treating patients with chronic pelvic pain and clinically suspected endometriosis, confirming the potential of its empiric use in these patients.
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“yet leuprolide relieves pain in women, regardless of whether they have endometriosis (Ling, 1999, Jenkins et al., 2008).”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Ling, 1999
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Metadata
- Authors
- Ling, F.
- Affiliations
- University of Tennessee Health Science Center (US)
- Corresponding author
- Ling, F
- Venue
- Obstetrics & Gynecology
- Published
- 1999-01
- Volume
- 93
- Issue
- 1
- Pages
- 51-58
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W2145262010
- Cited by
- 222
- References
- 27
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 13 · 2013: 11 · 2012: 13
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- chronic pelvic pain, endometriosis, dysmenorrhea, GnRH agonist therapy, laparoscopic confirmation
- MeSH terms
- Adolescent, Adult, Algorithms, Chronic Disease, Delayed-Action Preparations, Double-Blind Method, Endometriosis, Female, Humans, Middle Aged, Laparoscopy, Leuprolide, Pelvic Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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