The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Is the Role of the Small Intestine in First-Pass Metabolism Overemphasized?
Abstract
The primary function of the small intestine is to absorb nutrients and water. This is achieved by mixing food with digestive enzymes to increase the contact of foodstuffs with the absorptive cells of the mucosa. In humans, the small intestine is about 5 to 6 m in length and comprises approximately 1
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Cites
Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., & Guengerich, F. P. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22379-5 · Cited by 2,785 · cited 1×
“The average total cytochrome P-450 content in human intestine, about 20 pmol/mg microsomal protein, was found to be much lower than that in the liver (300 pmol/mg microsomal protein) (Peters and Kremers, 1989; Shimada et al., 1994).”
Ged, C., Rouillon, J., Pichard, L., Combalbert, J., Bressot, N., Bories, P., Michel, H., Beaune, P., & Maurel, P. (1989) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1989.tb03516.x · Cited by 333
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Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation
Kim, H. J., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40126j · Cited by 750
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Martinez, M. N., & Amidon, G. L. (2002) · The Journal of Clinical Pharmacology · doi:10.1177/00970002042006005 · Cited by 536
Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons
Ramesh, A., Walker, S. A., Hood, D. B., Guillén, M. D., Schneider, K., & Weyand, E. H. (2004) · International Journal of Toxicology · doi:10.1080/10915810490517063 · Cited by 498
Metadata
- Authors
- Lin, J. H., Chiba, M., & Baillie, T. A.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 51
- Issue
- 2
- Pages
- 135-157
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2162740038
- Cited by
- 352
- References
- 2
- FWCI
- 14.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Is the Role of the Small Intestine in First-Pass Metabolism Overemphasized? https://app.cochat.ai/papers/10.1016/s0031-6997(24)01402-9
- The paper
- Lin, J. H., Chiba, M., & Baillie, T. A. (1999). Is the Role of the Small Intestine in First-Pass Metabolism Overemphasized? Pharmacological Reviews. https://doi.org/10.1016/s0031-6997(24)01402-9
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
