The DOI matches its Crossref record.
Pharmacology of opioids.
Abstract
The concept of multiple opioid receptors reconciles a large body of clinical and pharmacological data. Recent studies have shown that there are also multiple opioid binding sites. It would appear that there is considerable variability between species in both the specificity and selectivity of opioid receptors. This issue has not been explored systematically regarding opioid binding sites. Better characterization of the pharmacological profiles and receptor binding specificity for different species may help resolve some of the apparent disparities. The number of putative receptors now number nearly a dozen. Already subspecies of mu, kappa, and sigma receptors are being postulated. Both pharmacological and neurochemical methods may reveal even more. Some of the newer kappa agonists differ in their pharmacology from the prototypic kappa agonist ethylketazocine.
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Citations
Cited by
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Psychotomimesis Mediated by κ Opiate Receptors
Pfeiffer, A., Brantl, V., Herz, A., & Emrich, H. M. (1986) · Science · doi:10.1126/science.3016896 · Cited by 857
Clark, D., & White, F. J. (1987) · Synapse · doi:10.1002/syn.890010408 · Cited by 660
A Controlled Trial of Buprenorphine Treatment for Opioid Dependence
Johnson, R. E. (1992) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1992.03480200058024 · Cited by 572
Schultz, J. E. J., Hsu, A. K., & Gross, G. J. (1996) · Circulation Research · doi:10.1161/01.res.78.6.1100 · Cited by 366
Metadata
- Authors
- Martin, W. R.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 1983-12
- Volume
- 35
- Issue
- 4
- Pages
- 283-323
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W4406969490
- Cited by
- 648
- References
- 0
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- closed
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