Oxytocin causes a long-term decrease of blood pressure in female and male rats
Abstract
The aim of the present study was to investigate the long-term effects of oxytocin (OXY) on blood pressure (BP) and heart rate (HR) in conscious female and male rats. For this purpose, subcutaneous (SC) (0.01, 0.1, and 1 mg/kg) or intracerebroventricular (ICV) (1 microgram/kg) injections of OXY were given during 5-day periods. BP and HR were measured daily. A significant decrease in BP, without affecting HR, compared to saline-treated controls was seen in response to 0.1 (males: p < 0.01, females: p < 0.001) and 1 mg/kg (p < 0.001) of OXY given SC. BP gradually returned to preexperimental levels within 10 days after the last injection in male rats but, in females, the significant lowering of BP remained unchanged during this period. Also OXY ICV (1 microgram/kg) decreased BP (p < 0.05 after one day, p < 0.001 after 5 days of injections). This effect was still present 8 days after the last injection (p < 0.05). These results indicate that OXY may induce a long-term lowering of BP.
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Oxytocin promotes the establishment of bonding or attachment between individuals.
“One important function of oxytocin is to promote the establishment of bonding or attachment between individuals.”
From The Oxytocinergic System as a Mediator of Anti-stress and Instorative Effects Induced by Nature: The Calm and Connection Theory (2021) · cites this paper as Petersson et al., 1996
Injections of oxytocin into the brain of female and male voles can initiate the development of bonds between two individuals.
“Injections of oxytocin into the brain of female and male voles can initiate the development of bonds between two individuals, and this effect involves an experience of enhanced salience of the sensory cues from “the other individual,” facilitated memory formation of “the other one,” activation of the reward center, and also decreased stress levels.”
From The Oxytocinergic System as a Mediator of Anti-stress and Instorative Effects Induced by Nature: The Calm and Connection Theory (2021) · cites this paper as Petersson et al., 1996
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References 20 · Cited by 229
- Authors
- PETERSSON, M., ALSTER, P., LUNDEBERG, T., & UVNÄS-MOBERG, K.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- PETERSSON, MARIA
- ORCID
- PETERSSON, MARIA
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 60
- Issue
- 5
- Pages
- 1311-1315
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2130079646
- Cited by
- 229
- References
- 20
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 9 · 2019: 11 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 13 · 2014: 11 · 2013: 12 · 2012: 6
- FWCI
- 16.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- oxytocin, blood pressure, heart rate, sex differences, intracerebroventricular administration, subcutaneous administration, rats
- MeSH terms
- Animals, Blood Pressure, Depression, Chemical, Female, Heart Rate, Injections, Intraventricular, Injections, Subcutaneous, Male, Oxytocin, Time Factors, Rats, Sprague-Dawley, Rats
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