The DOI matches its Crossref record; 233 of the 239 references it cites were found in a registry or an index.
Polyhydroxylated alkaloids—Natural occurrence and therapeutic applications
Abstract
Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and are arousing great interest as tools to study cellular recognition and as potential therapeutic agents. However, only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.
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“Swainsonine (mannose analogue) and castanospermine (glucose analogue) are iminosugar alkaloid glycosidases inhibitors, which also express anticancer properties and act on the protein-folding machinery [248].”
From GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review (2022) · cites this paper as [248]
Citations
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Cited by
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Potential of Cameroonian Plants and Derived Products against Microbial Infections: A Review
Kuete, V. (2010) · Planta Medica · doi:10.1055/s-0030-1250027 · Cited by 716
α- and β-Glucosidase inhibitors: chemical structure and biological activity
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The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens
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Metadata
- Authors
- Watson, A. A., Fleet, G. W. J., Asano, N., Molyneux, R. J., & Nash, R. J.
- Affiliations
- University of Oxford (GB)
- Hokuriku University (JP)
- Western Regional Research Center (US)
- Aberystwyth University (GB)
- Corresponding author
- Nash, Robert J.
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 56
- Issue
- 3
- Pages
- 265-295
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W2085285145
- Cited by
- 714
- References
- 239
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 17 · 2023: 12 · 2022: 20 · 2021: 21 · 2020: 25 · 2019: 28 · 2018: 20 · 2017: 18 · 2016: 33 · 2015: 29 · 2014: 51 · 2013: 49 · 2012: 41
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Keywords
- polyhydroxylated alkaloids, natural products, glycosidase inhibitors, plant alkaloids, cellular recognition, therapeutic applications, natural product isolation
- MeSH terms
- Alkaloids, Animals, Enzyme Inhibitors, Glycoside Hydrolases, Toxicity Tests
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