The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
Plasmodium falciparum antimalarial drug susceptibility on the north- western border of Thailand during five years of extensive use of artesunate-mefloquine.
Open accessAbstract
Following a marked decline in the efficacy in vivo of mefloquine between 1990 and 1994, a combination of artesunate (4 mg/kg/d for 3 d) and mefloquine (25 mg/kg) has been used as first line treatment of uncomplicated falciparum malaria in camps for displaced persons located along the north-western border of Thailand. Antimalarial drug susceptibility of fresh isolates of Plasmodium falciparum from this population was evaluated using a radioisotope microdilution assay between 1995 and 1999. In total, 268 isolates were collected, of which 189 were from primary infections and 79 from recrudescent infections. The geometric mean 50% inhibitory concentration (IC50) values from primary infections were: dihydroartemisinin 1.2 ng/mL, artesunate 1.6 ng/mL, artemether 4.8 ng/mL, atovaquone 0.4 ng/mL, lumefantrine 32 ng/mL, chloroquine 149 ng/mL, quinine 354 ng/mL, mefloquine 27 ng/mL and halofantrine 4.1 ng/mL. A significant positive correlation was found between the susceptibility in vitro to artesunate and quinine (r = 0.43, P < 0.001), mefloquine (r = 0.46, P < 0.001), and halofantrine (r = 0.51, P < 0.001). These levels of resistance in vitro are among the highest reported and confirm continuing high level multidrug resistance in this area. Despite intensive use of the combination between 1995 and 1999 there has been a significant improvement in mefloquine sensitivity (P < 0.001) and artesunate sensitivity (P < 0.001). This supports observations in vivo that the combination of artesunate and mefloquine has reversed the previous decline in mefloquine sensitivity.
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“There are no reliable malaria preventative measures [17]–[19] for pregnant women and treatment options are limited because of a high prevalence of multidrug resistant P. falciparum and because primaquine for radical cure of vivax malaria is contraindicated in pregnancy. [20]”
From Effect of Early Detection and Treatment on Malaria Related Maternal Mortality on the North-Western Border of Thailand 1986-2010 (2012) · cites this paper as [20]
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Nosten, F., van Vugt, M., Price, R., Luxemburger, C., Thway, K., Brockman, A., McGready, R., ter Kuile, F., Looareesuwan, S., & White, N. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02505-8 · Cited by 500
Self-citationAntimalarial drug resistance and combination chemotherapy
White, N. J. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0426 · Cited by 477
Self-citationEffects of artemisinin derivatives on malaria transmissibility
Price, R. N., Nosten, F. H., Luxemburger, C., ter Kuile, F. O., Paiphun, L., Price, R. N., Luxemburger, C., Chongsuphajaisiddhi, T., White, N. J., Price, R. N., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91488-9 · Cited by 462
Self-citationPrice, R. N., Cassar, C. A., Brockman, A., Duraisingh, M. T., van Vugt, M., White, N. J., Nosten, F. H., & Krishna, S. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.12.2943 · Cited by 276
Self-citationPreventing antimalarial drug resistance through combinations
White, N. J. (1998) · Drug Resistance Updates · doi:10.1016/s1368-7646(98)80208-2 · Cited by 262
Self-citationVariations in frequencies of drug resistance in Plasmodium falciparum
Rathod, P. K., McErlean, T., & Lee, P.-C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9389 · Cited by 252
Mefloquine-resistant falciparum malaria on the Thai-Burmese border
Nosten, F. H., ter Kuile, F. O., Chongsuphajaisiddhi, T., White, N. J., ter Kuile, F. O., Luxemburger, C., Webster, H. K., Edstein, M. D., Phaipun, L., Thew, K. L., et al. (1991) · The Lancet · doi:10.1016/0140-6736(91)92798-7 · Cited by 236
Self-citationThe epidemiology of malaria in a Karen population on the western border of Thailand.
Luxemburger, C., Thwai, K. L., White, N. J., Webster, H. K., Kyle, D. E., Maelankirri, L., Chongsuphajaisiddhi, T., & Nosten, F. (1996) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(96)90102-9 · Cited by 233
Self-citationNosten, F. H., Luxemburger, C., ter Kuile, F. O., Woodrow, C. J., Eh, J. P., Chongsuphajaisiddhi, T., & White, N. J. (1994) · The Journal of Infectious Diseases · doi:10.1093/infdis/170.4.971 · Cited by 229
Self-citationvan Vugt, M., Brockman, A., Gemperli, B., Luxemburger, C., Gathmann, I., Royce, C., Slight, T., Looareesuwan, S., White, N. J., & Nosten, F. H. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.1.135 · Cited by 170
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White, N. J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21682 · Cited by 1,254
Self-citationArtesunate versus quinine for treatment of severe falciparum malaria: a randomised trial.
(2005) · The Lancet · doi:10.1016/s0140-6736(05)67176-0 · Cited by 1,050
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
Price, R. N., Uhlemann, A., Brockman, A., McGready, R. M., Ashley, E. A., Phaipun, L., Patel, R., Laing, K. G., Looareesuwan, S., White, N. J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16767-6 · Cited by 849
Self-citationMedical need, scientific opportunity and the drive for antimalarial drugs
Ridley, R. G. (2002) · Nature · doi:10.1038/415686a · Cited by 792
Artemisinin-Based Combination Treatment of Falciparum Malaria
Nosten, F. H., & White, N. J. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.181 · Cited by 663
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Metadata
- Authors
- Brockman, A., Price, R. N., van Vugt, M., Heppner, D. G., Walsh, D., Sookto, P., Wimonwattrawatee, T., Looareesuwan, S., White, N. J., & Nosten, F.
- Affiliations
- Mahidol University (TH)
- John Radcliffe Hospital (GB)
- Armed Forces Research Institute of Medical Science (TH)
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-09
- Volume
- 94
- Issue
- 5
- Pages
- 537-544
- ISSN
- 0035-9203 (ISSN-L)
- PMC
- PMC4340572
- OpenAlex
- W2132714058
- Cited by
- 185
- References
- 28
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 5 · 2013: 7 · 2012: 7
- FWCI
- 11.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Wellcome Trust (074637)
- University of Oxford
- Mahidol University
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pharmaceutical Quality and Counterfeiting
- Keywords
- Plasmodium falciparum, antimalarial drug susceptibility, mefloquine resistance, multidrug resistance, artesunate, quinine, halofantrine, atovaquone, lumefantrine, dihydroartemisinin, chloroquine, displaced persons camps, recrudescent infection
- MeSH terms
- Artesunate, Adolescent, Adult, Aged, Animals, Antimalarials, Child, Child, Preschool, Dose-Response Relationship, Drug, Drug Combinations, Female, Humans, Infant, Lethal Dose 50, Male, Microbial Sensitivity Tests, Middle Aged, Plasmodium falciparum, Quality Control, Sesquiterpenes, Thailand, Mefloquine, Confounding Factors, Epidemiologic, Malaria, Falciparum, Artemisinins
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