The DOI matches its Crossref record; 26 of the 28 references it cites were found in a registry or an index.
Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria
Abstract
The potential for Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) dipstick tests to predict antimalarial treatment failure was investigated in a prospective study in Thailand of 38 patients admitted with severe malaria and 54 hospitalized with uncomplicated P. falciparum infections. Of these, 40 had subsequent recrudescence of their infections. Overall, 89% of patients with severe malaria and 61% of patients with uncomplicated malaria had positive PfHRP-2 dipstick tests for > 2 weeks following the start of treatment. Persistence was correlated positively with admission parasite counts, PfHRP-2 intensity scores and disease severity. PfHRP-2 tests which remained positive for > 2 weeks and PfHRP-2 reactive intensity scores on admission, at day 7 and day 14 did not predict treatment failure independent of admission parasitaemia. Freezing and thawing the blood samples did not significantly affect PfHRP-2 results tested by the dipstick technique. The PfHRP-2 dipstick test provides a useful indicator of recent severe malaria, but does not predict the therapeutic response.
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“An important weakness of RDT-HRP2 tests is the prolonged half-life of the antigen. HRP-2 can be identified in plasma samples several weeks after parasite clearance, and therefore cannot be used to distinguish current from recent infection [23–25].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [23]
In the citing paper
“These shortcomings hinder the use of existing RDT for managing malaria, and also for monitoring treatment efficacy [23–25].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [23]
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Metadata
- Authors
- Mayxay, M., Pukrittayakamee, S., Chotivanich, K., Looareesuwan, S., & White, N. J.
- Affiliations
- Mahidol University (TH)
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-03
- Volume
- 95
- Issue
- 2
- Pages
- 179-182
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W2012795621
- Cited by
- 175
- References
- 28
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 4 · 2015: 13 · 2014: 12 · 2013: 11 · 2012: 11
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Keywords
- Plasmodium falciparum, HRP-2, treatment failure prediction, malaria recrudescence, severe malaria, uncomplicated falciparum malaria, parasitemia
- MeSH terms
- Histidine-Rich Glycoprotein, Adult, Antimalarials, Humans, Prospective Studies, Proteins, Reagent Kits, Diagnostic, Recurrence, Sensitivity and Specificity, Specimen Handling, Cryopreservation, Malaria, Falciparum, Treatment Failure
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