The DOI matches its Crossref record; 17 of the 20 references it cites were found in a registry or an index.
Adrenal lesion in multiple endocrine neoplasia type 1
Abstract
Background Multiple endocrine neoplasia (MEN) type 1 is accompanied by adrenal involvement, but characteristics and clinical handling of this lesion have been insufficiently explored.Methods Patients with MEN 1 (n = 43) were monitored (mean, 6.3 years) with annual biochemical and radiologic adrenal evaluation. Adrenal specimens were examined by in situ RNA-RNA hybridization for expression of the MEN1 candidate gene phospholipase C beta 3 (PLC beta 3) and immunostaining for insulin-like growth factor-1 receptor.Results Altogether 17 patients (40%) displayed adrenal enlargement, which was limited to the adrenal cortex and showed signs of progression, marked atypia, and cancer development in three of them. Only the carcinoma exhibited adrenocortical hormone excess. PLC beta 3 was expressed in the hyperplastic and adenomatous proliferation but not the carcinoma. Pancreatic endocrine tumors with insulin-proinsulin excess were overrepresented in the patients with adrenocortical involvement, but significant insulin-like growth factor-1 receptor immunoreactivity was restricted to the carcinoma.Conclusions The prevalent adrenocortical lesion associated with MEN 1 requires regular attention because of malignant potential. It was unrelated to loss of constitution heterozygosity for the MEN1 locus (11q13) and PLC beta 3 expression, except for the cortical carcinoma exhibiting allelic losses involving also the Wiedemann-Beckwith gene at 11p15. Mechanisms for mitogenic relationships between the pancreatic and adrenal lesions of MEN 1 demand further clarification.
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“Associated adrenal lesions, mainly ACAs and uni- or bilateral hyperplasia, occur in 20% to 55% of MEN1 cases (45–48).”
From Adrenocortical carcinoma (2014) · cites this paper as [46]
In the citing paper
“A small fraction of patients with MEN1 will develop ACC (46–51).”
From Adrenocortical carcinoma (2014) · cites this paper as [46]
Citations
Cites
Mutation and cancer: statistical study of retinoblastoma
Knudson, A. G. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.4.820 · Cited by 7,612
Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma
Larsson, C., Skogseid, B. M., Öberg, K., Nakamura, Y., & Nordenskjöld, M. (1988) · Nature · doi:10.1038/332085a0 · Cited by 1,025
Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.
Koufos, A., Grundy, P. E., Morgan, K., Aleck, K. A., Hadro, T. A., Lampkin, B. C., Kalbakji, A., & Cavenee, W. K. (1989) · Europe PMC (PubMed Central) · Cited by 454
FAMILIAL MULTIPLE ENDOCRINE ADENOMA-PEPTIC ULCER COMPLEX
Ballard, H. S., Frame, B., & Hartsock, R. J. (1964) · Medicine · doi:10.1097/00005792-196407000-00003 · Cited by 440
Monoclonal antibodies to receptors for insulin and somatomedin-C.
Kull, F. C., Jacobs, S., Su, Y. F., Svoboda, M. E., Wyk, J. J. V., & Cuatrecasas, P. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32449-9 · Cited by 423
Clinical and genetic features of adrenocortical lesions in multiple endocrine neoplasia type 1
Skogseid, B. M., Larsson, C., Lindgren, P. G., Kvanta, E., Rastad, J., Theodorsson, E., WIDE, L. E., Wilander, E., & Öberg, K. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.1.1352309 · Cited by 233
Multiple Endocrine Neoplasia Type 1: A 10-Year Prospective Screening Study in Four Kindreds*
Skogseid, B. M., Eriksson, B. K., Lundqvist, G., Lörelius, L., Rastad, J., WIDE, L. E., Åkerström, G., & Öberg, K. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-2-281 · Cited by 227
Vasen, H. F. A. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.12.2717 · Cited by 120
Multiple Endocrine Neoplasia Type 1: Clinical Features and Screening
Skogseid, B. M., Rastad, J., & Öberg, K. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30112-9 · Cited by 103
Juhlin, C., Holmdahl, R., Johansson, H. E., Rastad, J., Åkerström, G., & Klareskog, L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.9.2990 · Cited by 78
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Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892
Goudet, P., Murat, A., Binquet, C., Cardot‐Bauters, C., Costa, A., Ruszniewski, P. B., Niccoli, P., Ménégaux, F., Chabrier, G., Borson‐Chazot, F., et al. (2009) · World Journal of Surgery · doi:10.1007/s00268-009-0290-1 · Cited by 350
Gatta-Cherifi, B., Chabre, O., Murat, A., Niccoli, P., Cardot-Bauters, C., Rohmer, V, Young, J., Delemer, B., Du Boullay, H., Verger, M. F., et al. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-0679 · Cited by 230
Causes of Death and Prognostic Factors in Multiple Endocrine Neoplasia Type 1
Ito, T., Igarashi, H., Uehara, H., Berna, M. J., & Jensen, R. T. (2013) · Medicine · doi:10.1097/md.0b013e3182954af1 · Cited by 218
Giraud, S., Zhang, C. X., Sinilnikova, O. M., Wautot, V., Salandre, J., Buisson, N., Waterlot, C., Bauters, C. C., Porchet, N., Aubert, J., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301953 · Cited by 210
Metadata
- Authors
- Skogseid, B., Rastad, J., Gobl, A., Larsson, C., Backlin, K., Juhlin, C., Åkerström, G., & Öberg, K.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Skogseid, Britt
- Venue
- Surgery
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 118
- Issue
- 6
- Pages
- 1077-1082
- ISSN
- 0039-6060 (ISSN-L)
- OpenAlex
- W1972860148
- Cited by
- 111
- References
- 20
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 7 · 2015: 4 · 2013: 4 · 2012: 2
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- multiple endocrine neoplasia type 1, adrenal mass, adrenocortical carcinoma, adrenal hyperplasia, IGF-1 receptor, pancreatic neuroendocrine tumors, Beckwith-Wiedemann syndrome, 11p15, tumor progression
- MeSH terms
- Adrenal Gland Diseases, Adrenal Gland Neoplasms, Adrenal Glands, Adult, Aged, Aged, 80 and over, Female, Humans, Immunoenzyme Techniques, Isoenzymes, Male, Middle Aged, Pancreatic Diseases, Type C Phospholipases, RNA, Messenger, In Situ Hybridization, Receptor, IGF Type 1, Multiple Endocrine Neoplasia Type 1, Phospholipase C beta
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