The DOI matches its Crossref record.
Giant cell myocarditis after mitral valve replacement: Case report and studies of the nature of giant cells
Abstract
A 22-year-old man with Marfan's syndrome and a history of antinuclear antibody-positive hepatitis died 25 days after undergoing cardiac valve replacement surgery for mitral valve prolapse. Giant cell myocarditis was found at autopsy. The multinucleated giant cells were shown by immunoperoxidase techniques to contain lysozyme, but not myosin or creatine phosphokinase, suggesting that they were derived from macrophage, rather than myocyte, precursors.
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In the citing paper
“In well-known forms of autoimmune myocarditis such as giant cell myocarditis and cardiac sarcoidosis, macrophages have been identified as a significant contributor to the formation of multinucleated giant cells or granulomas”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [110]
In the citing paper
“Histopathologic observations reveal myocardial infiltration of multinucleated giant cells along with lymphocytes and eosinophils in this condition.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [110]
In the citing paper
“multinucleated giant cells stained positive for macrophage or other myeloid cell markers in both clinical settings and animal models.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [110]
In the citing paper
“Macrophages also play a pivotal role in giant cell myocarditis”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [110]
Citations
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No references could be resolved yet.
Research works printed but not linked: 23
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Cited by
Sorted by citations
Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51
Metadata
- Authors
- Rabson, A. B., Schoen, F. J., Warhol, M. J., Mudge, G. H., & Collins, J. J.
- ORCID
- Rabson, Arnold B.
- Venue
- Human Pathology
- Publisher
- Elsevier BV
- Published
- 1984-06
- Volume
- 15
- Issue
- 6
- Pages
- 585-587
- ISSN
- 0046-8177 (ISSN-L)
- OpenAlex
- W2021752992
- Cited by
- 24
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2014: 2 · 2012: 1
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- giant cell myocarditis, mitral valve replacement, Marfan syndrome, mitral valve prolapse, multinucleated giant cells, lysozyme, macrophage precursors
- MeSH terms
- Adult, Humans, Male, Marfan Syndrome, Mitral Valve Prolapse, Myocarditis
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