Androgen regulation of gene expression.
Abstract
The biological action of androgenic male sex steroid hormones in prostate tissue is mediated by the androgen receptor, a nuclear transcription factor. The transcriptional program of androgenic signaling in the prostate consists of thousands of gene targets whose products play a role in almost all cellular functions, including cellular proliferation, survival, lipid metabolism, and differentiation. This review will provide a summary of the most recent data regarding androgen-regulated target genes and modulation of androgen receptor activity, especially with regard to androgen-dependent and castration-recurrent prostate cancer.
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The androgen receptor (AR) is a nuclear hormone receptor transcription factor that mediates androgen effects on target tissues and plays a central role in prostate cancer development and progression.
“The androgen receptor (AR), which is a member of the nuclear hormone receptor superfamily of proteins, is the transcription factor that is responsible for mediating the effects of androgens upon target tissues, and it has been demonstrated to play a central role in the development and progression of prostate cancer.”
From Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer (2011) · cites this paper as [4]
As a transcription factor, the AR regulates the expression of thousands of both coding and noncoding RNA targets.
“As a transcription factor, the AR regulates the expression of thousands of both coding and noncoding RNA targets (4,7).”
From Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer (2011) · cites this paper as [4]
A large proportion of CR prostate tumors maintain expression of a functional AR.
“Despite being resistant to androgen ablation therapy, it was observed that a large proportion of CR prostate tumors maintain expression of a functional androgen receptor (AR)”
From Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer (2011) · cites this paper as [4]
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References 132 · Cited by 117
- Authors
- Lamont, K. R., & Tindall, D. J.
- Affiliations
- Mayo Clinic (US)
- Venue
- Advances in cancer research
- Publisher
- Elsevier
- Published
- 2010
- Volume
- 107
- Pages
- 137-162
- ISSN
- 0065-230X (ISSN-L)
- OpenAlex
- W3133644571
- Cited by
- 117
- References
- 132
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 12 · 2015: 11 · 2014: 5 · 2013: 15 · 2012: 16
- FWCI
- 111.52
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in cancer research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgen receptor, androgen-regulated gene expression, prostate cancer, androgen-dependent prostate cancer, castration-resistant prostate cancer, androgen signaling, nuclear transcription factors, gene targets, cell proliferation, lipid metabolism, cell differentiation
- MeSH terms
- Androgens, Cell Differentiation, Humans, Lipids, Male, Prostatic Neoplasms, Receptors, Androgen, Gene Expression Regulation, Neoplastic, Gene Targeting, Cell Proliferation
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