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Cited by 109Developmental Biology and Gene RegulationNeurobiology and Insect Physiology ResearchAxon Guidance and Neuronal Signaling

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Chapter 5 Principles of Drosophila Eye Differentiation

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Cagan, Ross·2009·Current Topics in Developmental Biology
DOI 10.1016/s0070-2153(09)89005-4PMC PMC2890271
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Abstract

The Drosophila eye is one of nature's most beautiful structures and one of its most useful. It has emerged as a favored model for understanding the processes that direct cell fate specification, patterning, and morphogenesis. Though composed of thousands of cells, each fly eye is a simple repeating pattern of perhaps a dozen cell types arranged in a hexagonal array that optimizes coverage of the visual field. This simple structure combined with powerful genetic tools make the fly eye an ideal model to explore the relationships between local cell fate specification and global tissue patterning. In this chapter, I discuss the basic principles that have emerged from three decades of close study. We now understand at a useful level some of the basic principles of cell fate selection and the importance of local cell-cell communication. We understand less of the processes by which signaling combines with morphogenesis and basic cell biology to create a correctly patterned neuroepithelium. Progress is being made on these fundamental issues, and in this chapter I discuss some of the principles that are beginning to emerge.

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Metadata

Authors
Cagan, R.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Cagan, Ross
ORCID
Cagan, Ross
Venue
Current Topics in Developmental Biology
Publisher
Elsevier
Published
2009
Volume
89
Pages
115-135
ISSN
0070-2153 (ISSN-L)
DOI
10.1016/s0070-2153(09)89005-4
PMC
PMC2890271
OpenAlex
W1759354465
Cited by
109
References
2
Citations by year
2026: 1 · 2025: 8 · 2024: 16 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 11 · 2018: 14 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 3
FWCI
5.75
Type
book chapter
Language
en
Open access
Locations
  • Current topics in developmental biology/Current Topics in Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Eye Institute (R01EY011495)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords
Drosophila eye, cell fate specification, tissue patterning, morphogenesis, intercellular communication, neuroepithelium, signaling
MeSH terms
Animals, Cell Differentiation, Cell Movement, Drosophila melanogaster, Eye, Body Patterning

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