Chapter 12 Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis
Abstract
In response to various ethologically relevant stressors, oxytocin is released not only from neurohypophysial terminals into the blood, but also within distinct brain regions, for example the hypothalamic supraoptic and paraventricular nuclei, the septum and the amygdala in dependence on the quality and intensity of the stressor. Thus, oxytocin secretory activity may accompany the response of the hypothalamo-pituitary-adrenal (HPA) axis to a given stressor. In the present chapter, I try to summarize our efforts to reveal the physiological significance of intracerebrally released oxytocin in rats with respect to the regulation of the HPA axis under basal and stress conditions as well as with respect to behavioural stress responses. The effects of oxytocin appear to depend on the brain region studied and the state of activity of the animal (basal versus stress). In order to reveal interactions between the oxytocin system and the HPA axis, preliminary results are presented pointing towards a differential action of glucocorticoids on intracerebral and peripheral oxytocin release.
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Animal research documents a pivotal role of OT in promoting social bonding and attachment and in controlling fear and stress responses.
“The basis of this prevailing view has progressed from animal research documenting a pivotal role of OT in promoting social bonding and attachment (Insel, 1992;Young et al., 1998;Insel and Young, 2001;Kendrick, 2004;Neumann, 2009;Insel, 2010) and controlling fear and stress responses (Neumann, 2002;Huber et al., 2005;Lukas et al., 2011;Viviani et al., 2011;Knobloch et al., 2012) to pharmacological”
From Integrative Approaches Utilizing Oxytocin to Enhance Prosocial Behavior: From Animal and Human Social Behavior to Autistic Social Dysfunction (2012) · cites this paper as Neumann, 2002
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References 95 · Cited by 387
- Authors
- Neumann, I. D.
- Affiliations
- University of Regensburg (DE)
- Corresponding author
- Neumann, Inga D.
- ORCID
- Neumann, Inga D.
- Venue
- Progress in brain research
- Publisher
- Elsevier
- Published
- 2002
- Volume
- 139
- Pages
- 147-162
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1560037133
- Cited by
- 387
- References
- 95
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 12 · 2023: 18 · 2022: 18 · 2021: 18 · 2020: 13 · 2019: 19 · 2018: 18 · 2017: 19 · 2016: 24 · 2015: 23 · 2014: 12 · 2013: 20 · 2012: 20
- FWCI
- 28.94
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, stress coping, hypothalamic-pituitary-adrenal axis, glucocorticoids, stress behavior, supraoptic nucleus, paraventricular nucleus, amygdala, septum
- MeSH terms
- Adaptation, Psychological, Animals, Anxiety Disorders, Brain, Female, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Social Behavior, Stress, Psychological, Rats
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