Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder
Abstract
Posttraumatic stress disorder (PTSD) is associated with alterations in corticotrophin-releasing hormone (CRH) secretion. Plasma CRH levels, which are easily acquired, might serve as a predictor of hypothalamic CRH levels. Assessment of plasma CRH, adrenocorticotrophin hormone (ACTH), and cortisol levels in 31 veterans with PTSD, 30 traumatized veterans without PTSD matched on age, year, and region of deployment (traumacontrols), and 28 age-matched healthy controls (HCs) was carried out. Plasma CRH levels were higher in PTSD patients compared to both HCs (p=0.005) and traumacontrols (p=0.007). This led to our conclusion, that elevated plasma CRH levels are specifically related to PTSD and not to exposure to traumatic stress during deployment.
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Heightened levels of peripheral and central corticotropin-releasing hormone (CRH) occur in tandem with enhanced glucocorticoid sensitivity in PTSD.
“Heightened levels of peripheral and central corticotropin-releasing hormone (CRH; Baker et al, 2005;de Kloet et al, 2008) and elevated glucocorticoid receptor (GR) expression levels in lymphocytes (Matic et al, 2013) occur in tandem with enhanced glucocorticoid sensitivity in PTSD.”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as de Kloet et al, 2008
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References 15 · Cited by 115
- Authors
- de Kloet, C. S., Vermetten, E., Geuze, E., Lentjes, E. G. W. M., Heijnen, C. J., Stalla, G. K., & Westenberg, H. G. M.
- Affiliations
- Central Military Hospital (NL)
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Max Planck Institute of Psychiatry (DE)
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2007
- Volume
- 167
- Pages
- 287-291
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1543244495
- Cited by
- 115
- References
- 15
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 10 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 10
- FWCI
- 16.68
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- post-traumatic stress disorder, corticotropin-releasing factor, veterans, cortisol, hypothalamic-pituitary-adrenal axis, trauma exposure, biomarkers
- MeSH terms
- Adult, Corticotropin-Releasing Hormone, Female, Humans, Male, Psychiatric Status Rating Scales, Stress Disorders, Post-Traumatic, Veterans
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