The DOI matches its Crossref record.
Metabolism of carbamazepine.
Abstract
Thirty-two metabolites of carbamazepine, in addition to the 10,11-epoxide, have been isolated from enzymatically hydrolyzed urine by HPLC and identified by gas-chromatographic and mass-spectrometric techniques. Eight were sulfur-containing methylthio, methylsulfinyl, or methylsulfonyl derivatives. Eighteen new metabolites, including five iminostilbene derivatives that have not been described earlier, were found. All of the metabolites were formed by processes involving epoxidation and a peroxidation, the structures of the metabolites support the hypothesis that multiple epoxides and a cyclic peroxide are involved in the in vivo metabolism of carbamazepine by the rat and man.
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Citations
Cited by
Farré, M. L., Pérez, S., Kantiani, L., & Barceló, D. (2008) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2008.09.010 · Cited by 1,009
Stepan, A. F., Walker, D. P., Bauman, J., Price, D. A., Baillie, T. A., Kalgutkar, A. S., & Aleo, M. D. (2011) · Chemical Research in Toxicology · doi:10.1021/tx200168d · Cited by 698
Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk.
Shear, N. H., & Spielberg, S. P. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113798 · Cited by 687
Effect of berberine on the pharmacokinetics of substrates of CYP3A and P-gp
Qiu, W., Jiang, X. H., Liu, C. X., Ju, Y., & Jin, J. X. (2009) · Phytotherapy Research · doi:10.1002/ptr.2808 · Cited by 64
Metadata
- Authors
- Lertratanangkoon, K., & Horning, M. G.
- Venue
- Drug Metabolism and Disposition
- Publisher
- Elsevier BV
- Published
- 1982-01
- Volume
- 10
- Issue
- 1
- Pages
- 1-10
- ISSN
- 0090-9556 (ISSN-L)
- OpenAlex
- W2334925350
- Cited by
- 186
- References
- 0
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lertratanangkoon, K., & Horning, M. G. (1982). Metabolism of carbamazepine. Drug Metabolism and Disposition. https://doi.org/10.1016/s0090-9556(25)07827-4
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
