Lymphocyte infiltration and thickness of the nasal mucous membrane in perennial and seasonal allergic rhinitis
Open accessAbstract
We have used immunocytochemical techniques to study infiltration by lymphocytes in biopsy specimens of the nasal mucosal membrane in 24 atopic patients and 10 normal volunteers. Twelve patients had perennial rhinitis and 12 had seasonal allergic rhinitis (SR) to grass pollen. Biopsy specimens were taken both in and out of the pollen season in patients with SR. Biopsy specimens were strained with the indirect immunoperoxidase technique and monoclonal antibodies to CD3, CD4, CD8, CD22, and CD25. T helper cells (CD4+) and CD24+ cells were significantly more numerous in patients exposed to allergen (those with perennial rhinitis and SR in season) compared with normal volunteers, whereas values for SR out of season were intermediate. The thickness of the nasal epithelium was significantly (p < 0.05) greater in biopsy specimens from patients with perennial rhinitis (mean, 51.43 microns) than in those from patients with SR in season (median, 32.44 microns). These results suggest that in allergic rhinitis, natural exposure to allergen is accompanied by increased infiltration of the nasal mucous membrane by T-helper and CD25+ cells.
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Nasal epithelium is thicker in patients with AR after allergen challenge, but studies on epithelial thickness in AR without allergen challenge are conflicting.
“Nasal epithelium is thicker in patients with AR after allergen challenge,415,416 but studies on epithelial thickness in AR without allergen challenge are conflicting.415-417”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [417]
The Results (page not available in our copy) report thicker nasal epithelium in perennial rhinitis than in seasonal rhinitis during pollen season, but the difference from healthy volunteers was not statistically significant. This supports a qualified finding about thickness without deliberate challenge. The Discussion (page not available) mentions no reduction in thickness 24 hours after allergen provocation; it does not report thickening after challenge. (LLM, conf=0.86)
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References 30 · Cited by 58
Research works printed but not linked: 3
- Lozewicz S, Gomez E, Chalstrey S, et al. Cellular infiltra- tion in the upper respiratory tract and the effect of allergen provocation [Abstract]. J ALLERGY CLIN IMMUNOL 1989;83:307.
- Yamaguchi Y, Hayashi Y, Sugama Y, et al. Highly purified murine interleukin-5 stimulates eosinophil function and prolongs in vitro survival. J Exp Med 1988;167:1737-42.
- Varney VA, Jacobson MR, Sudderick RM, et al. Immu- nohistology of the nasal mucosa following allergen-in- duced rhinitis. Am Rev Respir Dis 1992;146:170-6.
- Authors
- Calderón, M. A., Lozewicz, S., Prior, A., Jordan, S., Trigg, C. J., & Davies, R. J.
- Affiliations
- St Bartholomew's Hospital (GB)
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 1994-03
- Volume
- 93
- Issue
- 3
- Pages
- 635-643
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W1977367278
- Cited by
- 58
- References
- 30
- Citations by year
- 2022: 1 · 2018: 1 · 2015: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- allergic rhinitis, perennial allergic rhinitis, grass pollen allergy, lymphocyte infiltration, nasal mucosa, mucosal thickness, T helper cells, CD4 cells, CD25+ cells, CD3+ T cells, CD8+ T cells, allergen exposure, pollen season
- MeSH terms
- Adolescent, Adult, Antibodies, Monoclonal, Biopsy, Cell Movement, Female, Rhinitis, Allergic, Seasonal, T-Lymphocytes, Helper-Inducer, Humans, Lymphocytes, Male, Nasal Mucosa, Reference Values, Rhinitis, Allergic, Perennial, Receptors, Interleukin-2, CD4-CD8 Ratio
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