Cited by 1,000RNA and protein synthesis mechanismsRNA modifications and cancerEnzyme Structure and Function

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Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Å Resolution

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Schluenzen, Frank, Tocilj, Ante, Zarivach, Raz, Harms, Joerg, Gluehmann, Marco, Janell, Daniela, Bashan, Anat, Bartels, Heike, Agmon, Ilana, Franceschi, François, Yonath, Ada·2000·Cell

DOI 10.1016/s0092-8674(00)00084-2

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Abstract

The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like contact closes and contributes to processivity and fidelity. Extended RNA helical elements that run longitudinally through the body transmit structural changes, correlating events at the particle's far end with the cycle of mRNA translocation at the decoding region. 96% of the nucleotides were traced and the main fold of all proteins was determined. The latter are either peripheral or appear to serve as linkers. Some may assist the directionality of translocation.

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Authors: Schluenzen, F., Tocilj, A., Zarivach, R., Harms, J., Gluehmann, M., Janell, D., Bashan, A., Bartels, H., Agmon, I., Franceschi, F., & Yonath, A.
Affiliations: Weizmann Institute of Science (IL)
ORCID: Schluenzen, Frank
Zarivach, Raz
Bashan, Anat
Agmon, Ilana
Yonath, Ada
Venue: Cell
Publisher: Elsevier BV
Published: 2000-09
Volume: 102
Issue: 5
Pages: 615-623
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)00084-2
OpenAlex: W2092617311
Cited by: 979
References: 72
Citations by year: 2026: 11 · 2025: 13 · 2024: 18 · 2023: 28 · 2022: 18 · 2021: 26 · 2020: 27 · 2019: 18 · 2018: 22 · 2017: 25 · 2016: 18 · 2015: 31 · 2014: 26 · 2013: 27 · 2012: 43
FWCI: 28.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4702 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM-34360, R01GM034360)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Keywords: small ribosomal subunit, ribosome structure, Thermus thermophilus, decoding center, tRNA binding, mRNA translocation, translation fidelity, ribosomal proteins
MeSH terms: Binding Sites, Models, Molecular, Nucleic Acid Conformation, Protein Conformation, Ribosomes, RNA, Bacterial, RNA, Messenger, RNA, Ribosomal, 16S, RNA, Transfer, Structure-Activity Relationship, Thermus thermophilus, Crystallography, X-Ray, Base Pairing

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Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Å Resolution

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