The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Accessory Protein Facilitated CFTR-CFTR Interaction, a Molecular Mechanism to Potentiate the Chloride Channel Activity
Open accessAbstract
The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes a chloride channel protein that belongs to the superfamily of ATP binding cassette (ABC) transporters. Phosphorylation by protein kinase A in the presence of ATP activates the CFTR-mediated chloride conductance of the apical membranes. We have identified a novel hydrophilic CFTR binding protein, CAP70, which is also concentrated on the apical surfaces. CAP70 consists of four PDZ domains, three of which are capable of binding to the CFTR C terminus. Linking at least two CFTR molecules via cytoplasmic C-terminal binding by either multivalent CAP70 or a bivalent monoclonal antibody potentiates the CFTR chloride channel activity. Thus, the CFTR channel can be switched to a more active conducting state via a modification of intermolecular CFTR-CFTR contact that is enhanced by an accessory protein.
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Cites
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M., & Cantley, L. C. (1997) · Science · doi:10.1126/science.275.5296.73 · Cited by 1,385
Cited by
Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A., van der Post, S., Svensson, F., Rodríguez‐Piñeiro, A. M., Nyström, E. E. L., et al. (2014) · Immunological Reviews · doi:10.1111/imr.12182 · Cited by 1,363
Mechanism and role of PDZ domains in signaling complex assembly
Harris, B. Z., & Lim, W. A. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.18.3219 · Cited by 830
PDZ Domains: Structural Modules for Protein Complex Assembly
Hung, A. Y., & Sheng, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100065200 · Cited by 699
New insights into cystic fibrosis: molecular switches that regulate CFTR
Guggino, W. B., & Stanton, B. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1949 · Cited by 432
Self-citationSingh, A. K., Riederer, B., Krabbenhöft, A., Rausch, B., Bonhagen, J., Lehmann, U., de Jonge, H. R., Donowitz, M., Yun, C., Weinman, E. J., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35541 · Cited by 364
Metadata
- Authors
- Wang, S., Yue, H., Derin, R. B., Guggino, W. B., & Li, M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 103
- Issue
- 1
- Pages
- 169-179
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2027085827
- Cited by
- 299
- References
- 2
- FWCI
- 21.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wang, S., Yue, H., Derin, R. B., Guggino, W. B., & Li, M. (2000). Accessory Protein Facilitated CFTR-CFTR Interaction, a Molecular Mechanism to Potentiate the Chloride Channel Activity. Cell. https://doi.org/10.1016/s0092-8674(00)00096-9
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