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Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance
Open accessAbstract
Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations. MPK4 kinase activity is required to repress SAR, as an inactive MPK4 form failed to complement mpk4. Analysis of mpk4 expressing the SA hydroxylase NahG and of mpk4/npr1 double mutants indicated that SAR expression in mpk4 is dependent upon elevated SA levels but is independent of NPR1. PDF1.2 and THI2.1 gene induction by jasmonate was blocked in mpk4 expressing NahG, suggesting that MPK4 is required for jasmonic acid-responsive gene expression.
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Cited by
MAP kinase signalling cascade in Arabidopsis innate immunity
Asai, T., Tena, G., Plotnikova, J., Willmann, M. R., Chiu, W.-L., Gomez-Gomez, L., Boller, T., Ausubel, F. M., & Sheen, J. (2002) · Nature · doi:10.1038/415977a · Cited by 2,726
Salicylic acid, a multifaceted hormone to combat disease
Vlot, A. C., Dempsey, D. A., & Klessig, D. F. (2009) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.050908.135202 · Cited by 2,568
Self-citationCell Signaling during Cold, Drought, and Salt Stress
Xiong, L., Schumaker, K. S., & Zhu, J.-K. (2002) · The Plant Cell · doi:10.1105/tpc.000596 · Cited by 2,372
Cross talk between signaling pathways in pathogen defense
Kunkel, B. N., & Brooks, D. M. (2002) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(02)00275-3 · Cited by 1,451
Li, J., Brader, G., & Palva, E. T. (2004) · The Plant Cell · doi:10.1105/tpc.016980 · Cited by 1,207
Metadata
- Authors
- Petersen, M., Brodersen, P., Naested, H., Andreasson, E., Lindhart, U., Johansen, B., Nielsen, H. B., Lacy, M., Austin, M. J., Parker, J. E., Sharma, S. B., Klessig, D. F., Martienssen, R., Mattsson, O., Jensen, A. B., & Mundy, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 103
- Issue
- 7
- Pages
- 1111-1120
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2026238074
- Cited by
- 1,035
- References
- 0
- FWCI
- 68.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Petersen, M., Brodersen, P., Naested, H., Andreasson, E., Lindhart, U., Johansen, B., Nielsen, H. B., Lacy, M., Austin, M. J., Parker, J. E., Sharma, S. B., Klessig, D. F., Martienssen, R., Mattsson, O., Jensen, A. B., & Mundy, J. (2000). Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance. Cell. https://doi.org/10.1016/s0092-8674(00)00213-0
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