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Sno Storm in the Nucleolus: New Roles for Myriad Small RNPs
Open accessAbstract
Biologists have known for decades that the nucleolus is the compartment of the eukaryotic cell most densely packed with RNA. But few would have guessed that, in addition to the ribosomal RNAs (rRNAs) at various stages of maturation, the nucleolus contains a multitude of discrete small RNA molecules. These small nucleolar RNAs, or snoRNAs, are responsible not only for orchestrating the cleavage events that cut the long pre-rRNA into 18S, 5.8S, and 28S molecules, but also for adding finishing touches to rRNAs as they assemble into the ultimate products of the nucleolus, the ribosomal subunits. These finishing touches include remodeling of certain rRNA uridines into pseudouridines and tagging of numerous ribose moieties with methyl groups. The amazing recent realization is that each of these modifications is directed by its own specific snoRNA that is packaged (as are all small nuclear RNAs) into a ribonucleoprotein (snoRNP) particle.
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Cited by
Endogenous and Silencing-Associated Small RNAs in Plants[W]
Llave, C., Kasschau, K. D., Rector, M. A., & Carrington, J. C. (2002) · The Plant Cell · doi:10.1105/tpc.003210 · Cited by 914
Bachellerie, J.-P., Cavaillé, J., & Hüttenhofer, A. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01402-5 · Cited by 668
Cavaillé, J., Buiting, K., Kiefmann, M., Lalande, M., Brannan, C. I., Horsthemke, B., Bachellerie, J.-P., Brosius, J., & Hüttenhofer, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250426397 · Cited by 601
A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ End
Mitchell, J. R., Cheng, J., & Collins, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.567 · Cited by 510
AdoMet-dependent methylation, DNA methyltransferases and base flipping
Cheng, X. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.18.3784 · Cited by 485
Metadata
- Authors
- Smith, C. M., & Steitz, J. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 89
- Issue
- 5
- Pages
- 669-672
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1972619373
- Cited by
- 312
- References
- 0
- FWCI
- 13.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Smith, C. M., & Steitz, J. A. (1997). Sno Storm in the Nucleolus: New Roles for Myriad Small RNPs. Cell. https://doi.org/10.1016/s0092-8674(00)80247-0
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