The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles
Open accessAbstract
We demonstrate that fizzy-related (fzr), a conserved eukaryotic gene, negatively regulates the levels of cyclins A, B, and B3. These mitotic cyclins that bind and activate cdk1(cdc2) are rapidly degraded during exit from M and during G1. While Drosophila fizzy has previously been shown to be required for cyclin destruction during M phase, fzr is required for cyclin removal during G1 when the embryonic epidermal cell proliferation stops and during G2 preceding salivary gland endoreduplication. Loss of fzr causes progression through an extra division cycle in the epidermis and inhibition of endoreduplication in the salivary gland, in addition to failure of cyclin removal. Conversely, premature fzr overexpression down-regulates mitotic cyclins, inhibits mitosis, and transforms mitotic cycles into endoreduplication cycles.
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Cites
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The Anaphase-Promoting Complex
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The Phosphatase Cdc14 Triggers Mitotic Exit by Reversal of Cdk-Dependent Phosphorylation
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Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis
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Metadata
- Authors
- Sigrist, S. J., & Lehner, C. F.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 90
- Issue
- 4
- Pages
- 671-681
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2136644864
- Cited by
- 425
- References
- 53
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sigrist, S. J., & Lehner, C. F. (1997). Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles. Cell. https://doi.org/10.1016/s0092-8674(00)80528-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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