Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila
Open accessAbstract
A nitric oxide (NO)/cyclic GMP (cGMP) signaling pathway is thought to play an important role in mammalian vasodilation during hypoxia. We show that Drosophila utilizes components of this pathway to respond to hypoxia. Hypoxic exposure rapidly induced exploratory behavior in larvae and arrested the cell cycle. These behavioral and cellular responses were diminished by an inhibitor of NO synthase and by a polymorphism affecting a form of cGMP-dependent protein kinase. Conversely, these responses were induced by ectopic expression of NO synthase. Perturbing components of the NO/cGMP pathway altered both tracheal development and survival during prolonged hypoxia. These results indicate that NO and protein kinase G contribute to Drosophila's ability to respond to oxygen deprivation.
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Genetic studies in Drosophila indicate that nitric oxide modifies the hypoxic response.
“Genetic studies in Drosophila indicate that nitric oxide (NO) modifies the hypoxic response (Wingrove and O'Farrell, 1999).”
From Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. (2008) · cites this paper as Wingrove and O'Farrell, 1999
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- Authors
- Wingrove, J. A., & O'Farrell, P. H.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Wingrove, James A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 98
- Issue
- 1
- Pages
- 105-114
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2754235
- OpenAlex
- W2106421836
- Cited by
- 249
- References
- 3
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 14 · 2014: 5 · 2013: 11 · 2012: 13
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM037193)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- nitric oxide, hypoxia, Drosophila, nitric oxide synthase, cGMP signaling, protein kinase G, cGMP-dependent protein kinase, cell cycle arrest, exploratory behavior, tracheal development, oxygen deprivation, NO synthase inhibitors
- MeSH terms
- Aging, Anaerobiosis, Animals, Cell Cycle, Drosophila, Exploratory Behavior, Cyclic GMP, Larva, Nitric Oxide, Polymorphism, Genetic, Protein Kinases, Signal Transduction, Cyclic GMP-Dependent Protein Kinases, Nitric Oxide Synthase
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