The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Open accessAbstract
Steroid hormones exert profound effects on differentiation, development, and homeostasis in higher eukaryotes through interactions with nuclear receptors. We describe a novel orphan nuclear receptor, termed the pregnane X receptor (PXR), that is activated by naturally occurring steroids such as pregnenolone and progesterone, and synthetic glucocorticoids and antiglucocorticoids. PXR exists as two isoforms, PXR.1 and PXR.2, that are differentially activated by steroids. Notably, PXR.1 is efficaciously activated by pregnenolone 16alpha-carbonitrile, a glucocorticoid receptor antagonist that induces the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo. Our results provide evidence for the existence of a novel steroid hormone signaling pathway with potential implications in the regulation of steroid hormone and sterol homeostasis.
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Citations
Cites
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Self-citationThe RXR heterodimers and orphan receptors
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Cited by
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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
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Self-citationThe PPARs: From Orphan Receptors to Drug Discovery
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Self-citationEndogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
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Metadata
- Authors
- Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterström, R. H., Perlmann, T., & Lehmann, J. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 92
- Issue
- 1
- Pages
- 73-82
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2035000881
- Cited by
- 1,539
- References
- 55
- FWCI
- 27.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterström, R. H., Perlmann, T., & Lehmann, J. M. (1998). An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway. Cell. https://doi.org/10.1016/s0092-8674(00)80900-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
