POP-1 and Anterior–Posterior Fate Decisions in C. elegans Embryos
Open accessAbstract
Blastomeres in C. elegans embryos execute lineage programs wherein the fate of a cell is correlated reproducibly with the division sequence by which that cell is born. We provide evidence that the pop-1 gene functions to link anterior-posterior cell divisions with cell fate decisions. Each anterior cell resulting from an anterior-posterior division appears to have a higher level of nuclear POP-1 protein than does its posterior sister. Genes in the C. elegans Wnt pathway are required for this inequality in POP-1 levels. We show that loss of pop-1(+) activity leads to several types of anterior cells adopting the fates of their posterior sisters. These results suggest a mechanism for the invariance of blastomere lineages.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
POP-1, a LEF-1/TCF-related protein, functions to repress gene expression.
“POP-1, a LEF-1/TCF-related protein, functions to repress gene expression, and Wnt signaling down-regulates the activity of POP-1 (15, 16, 21, 22, 30).”
Wnt signaling down-regulates the activity of POP-1.
“POP-1, a LEF-1/TCF-related protein, functions to repress gene expression, and Wnt signaling down-regulates the activity of POP-1 (15, 16, 21, 22, 30).”
Cited by
Sorted by citations
Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature · doi:10.1038/21674 · Cited by 624 · see citing works
Silencing of <i>Smed</i> -β <i>catenin1</i> generates radial-like hypercephalized planarians
Iglesias, M., Gomez-Skarmeta, J. L., Saló, E., & Adell, T. (2008) · Development · doi:10.1242/dev.020289 · Cited by 221 · see citing works
Ishitani, T., Ninomiya-Tsuji, J., & Matsumoto, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1379-1389.2003 · Cited by 212 · see citing works
Lo, M.-C., Gay, F., Odom, R., Shi, Y., & Lin, R. (2004) · Cell · doi:10.1016/s0092-8674(04)00203-x · Cited by 138 · see citing works
Self-citationYASUDA, J., & ICHIKAWA, H. (2007) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.83.16 · Cited by 6 · see citing works
- Authors
- Lin, R., Hill, R. J., & Priess, J. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Priess, James R
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 92
- Issue
- 2
- Pages
- 229-239
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2100140713
- Cited by
- 282
- References
- 0
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 4 · 2019: 8 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 6
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- POP-1, Wnt signaling, cell fate determination, Caenorhabditis elegans embryo, asymmetric cell division
- MeSH terms
- Animals, Antibodies, Monoclonal, Blastomeres, Cell Division, Cell Nucleus, DNA-Binding Proteins, High Mobility Group Proteins, Proto-Oncogene Proteins, Signal Transduction, Caenorhabditis elegans, Genes, Helminth, Body Patterning, Caenorhabditis elegans Proteins, Zebrafish Proteins, Wnt Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
