The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Positional Cloning Identifies Zebrafish one-eyed pinhead as a Permissive EGF-Related Ligand Required during Gastrulation
Open accessAbstract
The zebrafish one-eyed pinhead (oep) mutation disrupts embryonic development, resulting in cyclopia and defects in endoderm, prechordal plate, and ventral neuroectoderm formation. We report the molecular isolation of oep using a positional cloning approach. The oep gene encodes a novel EGF-related protein with similarity to the EGF-CFC proteins cripto, cryptic, and FRL-1. Wild-type oep protein contains a functional signal sequence and is membrane-associated. Following ubiquitous maternal and zygotic expression, highest levels of oep mRNA are found in the gastrula margin and in axial structures and forebrain. Widespread misexpression of both membrane-attached and secreted forms of oep rescues prechordal plate and forebrain development in mutant embryos but does not lead to the ectopic induction of these cell types in wild-type fish. These results establish an essential but permissive role for an EGF-related ligand during vertebrate gastrulation.
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Cites
A homeobox gene essential for zebrafish notochord development
Talbot, W. S., Trevarrow, B., Halpern, M. E., Melby, A. E., Farr, G., Postlethwait, J. H., Jowett, T., Kimmel, C. B., & Kimelman, D. (1995) · Nature · doi:10.1038/378150a0 · Cited by 465 · cited 4×
“specification in the embryo (Kimmel et al., 1989; Talbot et al., 1995; Driever et al., 1996; Haffter et al., 1996; Schier, 1997).”
BackgroundInfluentialSelf-citationHalpern, M. E., Thisse, C., Ho, R. K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E. S., Postlethwait, J. H., & Kimmel, C. B. (1995) · Development · doi:10.1242/dev.121.12.4257 · Cited by 178
Cited by
Vertebrate genome evolution and the zebrafish gene map
Postlethwait, J. H., Yan, Y.-L., Gates, M. A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E. S., Force, A., Gong, Z., et al. (1998) · Nature Genetics · doi:10.1038/ng0498-345 · Cited by 829
Self-citationAxis Development and Early Asymmetry in Mammals
Beddington, R. S. P., & Robertson, E. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80560-7 · Cited by 756
A systematic genome-wide analysis of zebrafish protein-coding gene function
Kettleborough, R. N. W., Busch-Nentwich, E. M., Harvey, S. A., Dooley, C. M., de Bruijn, E., van Eeden, F., Sealy, I., White, R. J., Herd, C., Nijman, I. J., et al. (2013) · Nature · doi:10.1038/nature11992 · Cited by 621
Cripto is required for correct orientation of the anterior–posterior axis in the mouse embryo
Ding, J., Yang, L., Yan, Y.-T., Chen, A., Desai, N., Wynshaw-Boris, A., & Shen, M. M. (1998) · Nature · doi:10.1038/27215 · Cited by 481
Structure and function of the notochord: an essential organ for chordate development
Stemple, D. L. (2005) · Development · doi:10.1242/dev.01812 · Cited by 443
Metadata
- Authors
- Zhang, J., Talbot, W. S., & Schier, A. F.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 92
- Issue
- 2
- Pages
- 241-251
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1976880781
- Cited by
- 459
- References
- 2
- FWCI
- 17.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhang, J., Talbot, W. S., & Schier, A. F. (1998). Positional Cloning Identifies Zebrafish one-eyed pinhead as a Permissive EGF-Related Ligand Required during Gastrulation. Cell. https://doi.org/10.1016/s0092-8674(00)80918-6
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