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LET-23 Receptor Localization by the Cell Junction Protein LIN-7 during C. elegans Vulval Induction
Open accessAbstract
In C. elegans, the anchor cell signal induces Pn.p cells to form the vulva by activating a conserved receptor tyrosine kinase pathway. lin-2 and lin-7 mutants exhibit a vulvaless phenotype similar to the phenotype observed when this signaling pathway is defective. We have found that LIN-7 is a cell junction-associated protein that binds to the LET-23 receptor tyrosine kinase. LET-23 is also localized to the cell junctions, and both LIN-2 and LIN-7 are required for this localization. LET-23 overexpression rescues the lin-2 or lin-7 vulvaless phenotype, suggesting that increased receptor density can compensate for mislocalization. These results suggest that proper localization of LET-23 receptor to the Pn.p cell junctions is required for signaling activity.
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Cited by
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Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M., & Cantley, L. C. (1997) · Science · doi:10.1126/science.275.5296.73 · Cited by 1,385
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Butz, S., Okamoto, M., & Südhof, T. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81736-5 · Cited by 548
Metadata
- Authors
- Simske, J. S., Kaech, S. M., Harp, S. A., & Kim, S. K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-04
- Volume
- 85
- Issue
- 2
- Pages
- 195-204
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2104008077
- Cited by
- 265
- References
- 0
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: LET-23 Receptor Localization by the Cell Junction Protein LIN-7 during C. elegans Vulval Induction. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81096-x
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- Simske, J. S., Kaech, S. M., Harp, S. A., & Kim, S. K. (1996). LET-23 Receptor Localization by the Cell Junction Protein LIN-7 during C. elegans Vulval Induction. Cell. https://doi.org/10.1016/s0092-8674(00)81096-x
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