Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling
Open accessAbstract
Frizzled family proteins have been described as receptors of Wnt signaling molecules. In Drosophila, the two known Frizzled proteins are associated with distinct developmental processes. Genesis of epithelial planar polarity requires Frizzled, whereas Dfz2 affects morphogenesis by wingless-mediated signaling. Dishevelled is required in both signaling pathways. Here, we use genetic and overexpression assays to show that Dishevelled activates JNK cascades. Rescue analysis reveals different protein domain requirements in Dishevelled for the two pathways; the C-terminal DEP domain is essential to rescue planar polarity defects and induce JNK signaling. Furthermore, the planar polarity-specific dsh1 allele is mutated in the DEP domain. Our results indicate that different Wnt/Fz signals activate distinct intracellular pathways, and Dishevelled discriminates among them by distinct domain interactions.
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Asymmetric membrane accumulation of Dsh is important for the non-canonical pathway and convergent extension movements.
“As mentioned above, asymmetric membrane accumulation of Dsh is important for the non-canonical pathway and convergent extension movements.118–120”
From Wnt signal transduction pathways (2008) · cites this paper as [118]
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References 66 · Cited by 801
- Authors
- Boutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Corresponding author
- Mlodzik, Marek
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 94
- Issue
- 1
- Pages
- 109-118
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2055557491
- Cited by
- 801
- References
- 66
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 6 · 2023: 15 · 2022: 16 · 2021: 18 · 2020: 15 · 2019: 9 · 2018: 9 · 2017: 16 · 2016: 17 · 2015: 23 · 2014: 17 · 2013: 21 · 2012: 37
- FWCI
- 17.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Keywords
- Dishevelled, JNK signaling, planar cell polarity, Wingless signaling, Frizzled receptors, Wnt signaling, DEP domain, Drosophila, protein domain interactions
- MeSH terms
- Dishevelled Proteins, Amino Acid Sequence, Animals, Drosophila, Eye, Membrane Proteins, Models, Genetic, Molecular Sequence Data, Phosphoproteins, Phosphorylation, Proto-Oncogene Proteins, Signal Transduction, Point Mutation, Sequence Homology, Amino Acid, Calcium-Calmodulin-Dependent Protein Kinases, Insect Proteins, Body Patterning, Mitogen-Activated Protein Kinases, Drosophila Proteins, Receptors, G-Protein-Coupled, JNK Mitogen-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Wnt1 Protein, Frizzled Receptors
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