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Perturbation of Nuclear Architecture by Long-Distance Chromosome Interactions
Open accessAbstract
SUMMARY: Position-effect variegation (PEV) describes the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. Using FISH, we have tested whether variegated expression of the eye-color gene brown in Drosophila is influenced by its nuclear localization. In embryonic nuclei, a heterochromatic insertion at the brown locus is always spatially isolated from other heterochromatin. However, during larval development this insertion physically associates with other heterochromatic regions on the same chromosome in a stochastic manner. These observations indicate that the brown gene is silenced by specific contact with centromeric heterochromatin. Moreover, they provide direct evidence for long-range chromosome interactions and their impact on three-dimensional nuclear architecture, while providing a cohesive explanation for the phenomenon of PEV.
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Citations
Cited by
Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
Lieberman-Aiden, E., van Berkum, N. L., Williams, L., Imakaev, M., Ragoczy, T., Telling, A., Amit, I., Lajoie, B. R., Sabo, P. J., Dorschner, M. O., et al. (2009) · Science · doi:10.1126/science.1181369 · Cited by 8,898
Grewal, S. I. S., & Jia, S. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2008 · Cited by 1,263
Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions
Lanctôt, C., Cheutin, T., Cremer, M., Cavalli, G., & Cremer, T. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2041 · Cited by 781
Coincidence, coevolution, or causation? DNA content, cellsize, and the C‐value enigma
GREGORY, T. R. (2001) · Biological Reviews · doi:10.1111/j.1469-185x.2000.tb00059.x · Cited by 730
Chiolo, I., Minoda, A., Colmenares, S. U., Polyzos, A., Costes, S. V., & Karpen, G. H. (2011) · Cell · doi:10.1016/j.cell.2011.02.012 · Cited by 527
Metadata
- Authors
- Dernburg, A. F., Broman, K. W., Fung, J. C., Marshall, W. F., Philips, J., Agard, D. A., & Sedat, J. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 85
- Issue
- 5
- Pages
- 745-759
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2091373076
- Cited by
- 423
- References
- 0
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dernburg, A. F., Broman, K. W., Fung, J. C., Marshall, W. F., Philips, J., Agard, D. A., & Sedat, J. W. (1996). Perturbation of Nuclear Architecture by Long-Distance Chromosome Interactions. Cell. https://doi.org/10.1016/s0092-8674(00)81240-4
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