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Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation
Open accessAbstract
The heterotrimeric Sec61p complex is a major component of the protein-conducting channel of the endoplasmic reticulum (ER) membrane, associating with either ribosomes or the Sec62/63 complex to perform co- and posttranslational transport, respectively. We show by electron microscopy that purified mammalian and yeast Sec61p complexes in detergent form cylindrical oligomers with a diameter of approximately 85 A and a central pore of approximately 20 A. Each oligomer contains 3-4 heterotrimers. Similar ring structures are seen in reconstituted proteoliposomes and native membranes. Oligomer formation by the reconstituted Sec61p complex is stimulated by its association with ribosomes or the Sec62/63p complex. We propose that these cylindrical oligomers represent protein-conducting channels of the ER, formed by ligands specific for co- and posttranslational transport.
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Cited by
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Self-citationProtein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Rapoport, T. A. (2007) · Nature · doi:10.1038/nature06384 · Cited by 977
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Natale, P., Brüser, T., & Driessen, A. J. M. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.015 · Cited by 542
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Metadata
- Authors
- Hanein, D., Matlack, K. E. S., Jungnickel, B., Plath, K., Kalies, K.-U., Miller, K. R., Rapoport, T. A., & Akey, C. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 87
- Issue
- 4
- Pages
- 721-732
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2157729659
- Cited by
- 341
- References
- 0
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hanein, D., Matlack, K. E. S., Jungnickel, B., Plath, K., Kalies, K.-U., Miller, K. R., Rapoport, T. A., & Akey, C. W. (1996). Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation. Cell. https://doi.org/10.1016/s0092-8674(00)81391-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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