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Prolyl Oligopeptidase
Open accessAbstract
Abstract Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new class of serine peptidases. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides, which relate to the induction of amnesia. The 1.4 A resolution crystal structure is presented here. The enzyme contains a peptidase domain with an α/β hydrolase fold, and its catalytic triad (Ser554, His680, Asp641) is covered by the central tunnel of an unusual β propeller. This domain makes prolyl oligopeptidase an oligopeptidase by excluding large structured peptides from the active site. In this way, the propeller protects larger peptides and proteins from proteolysis in the cytosol. The structure is also obtained with a transition state inhibitor, which may facilitate drug design to treat memory disorders.
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Cites
Kabsch, W., & Sander, C. (1983) · Biopolymers · doi:10.1002/bip.360221211 · Cited by 15,320
Cited by
Lambeir, A.-M., Durinx, C., Scharpé, S., & De Meester, I. (2003) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/713609354 · Cited by 955
α/β Hydrolase fold enzymes: the family keeps growing
Nardini, M., & Dijkstra, B. W. (1999) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(99)00037-8 · Cited by 829
Towler, P., Staker, B., Prasad, S. G., Menon, S., Tang, J., Parsons, T., Ryan, D., Fisher, M., Williams, D., Dales, N. A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311191200 · Cited by 696
Protein Repeats: Structures, Functions, and Evolution
Andrade, M. A., Perez-Iratxeta, C., & Ponting, C. P. (2001) · Journal of Structural Biology · doi:10.1006/jsbi.2001.4392 · Cited by 615
CD26, let it cut or cut it down
De Meester, I., Korom, S., Van Damme, J., & Scharpé, S. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01486-3 · Cited by 451
Metadata
- Authors
- Fülöp, V., Böcskei, Z., & Polgár, L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 94
- Issue
- 2
- Pages
- 161-170
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1764151989
- Cited by
- 496
- References
- 1
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
