The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Meiotic Recombination in C. elegans Initiates by a Conserved Mechanism and Is Dispensable for Homologous Chromosome Synapsis
Open accessAbstract
Chromosome segregation at meiosis I depends on pairing and crossing-over between homologs. In most eukaryotes, pairing culminates with formation of the proteinaceous synaptonemal complex (SC). In budding yeast, recombination initiates through double-strand DNA breaks (DSBs) and is thought to be essential for SC formation. Here, we examine whether this mechanism for initiating meiotic recombination is conserved, and we test the dependence of homologous chromosome synapsis on recombination in C. elegans. We find that a homolog of the yeast DSB-generating enzyme, Spo11p, is required for meiotic exchange in this metazoan, and that radiation-induced breaks partially alleviate this dependence. Thus, initiation of recombination by DSBs is apparently conserved. However, homologous synapsis is independent of recombination in the nematode, since it occurs normally in a C. elegans spo-11 null mutant.
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Cites
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Cited by
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
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Meiotic Chromosomes: Integrating Structure and Function
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Recombinational DNA double-strand breaks in mice precede synapsis
Mahadevaiah, S. K., Turner, J. M. A., Baudat, F., Rogakou, E. P., de Boer, P., Blanco-Rodríguez, J., Jasin, M., Keeney, S., Bonner, W. M., & Burgoyne, P. S. (2001) · Nature Genetics · doi:10.1038/85830 · Cited by 851
Recombination, Pairing, and Synapsis of Homologs during Meiosis
Zickler, D., & Kleckner, N. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016626 · Cited by 799
Metadata
- Authors
- Dernburg, A. F., McDonald, K., Moulder, G., Barstead, R., Dresser, M., & Villeneuve, A. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 94
- Issue
- 3
- Pages
- 387-398
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1969575610
- Cited by
- 772
- References
- 35
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Meiotic Recombination in C. elegans Initiates by a Conserved Mechanism and Is Dispensable for Homologous Chromosome Synapsis. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81481-6
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- Dernburg, A. F., McDonald, K., Moulder, G., Barstead, R., Dresser, M., & Villeneuve, A. M. (1998). Meiotic Recombination in C. elegans Initiates by a Conserved Mechanism and Is Dispensable for Homologous Chromosome Synapsis. Cell. https://doi.org/10.1016/s0092-8674(00)81481-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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