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Cited by 716

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling

Open access
Zhao, Keji, Wang, Weidong, Rando, Oliver J, Xue, Yutong, Swiderek, Kristine, Kuo, Ann, Crabtree, Gerald R·1998·Cell

Abstract

Lymphocyte activation is accompanied by visible changes in chromatin structure. We find that antigen receptor signaling induces the rapid association of the BAF complex with chromatin. PIP2, which is regulated by activation stimuli, is sufficient in vitro to target the BAF complex to chromatin, but it has no effect on related chromatin remodeling complexes containing SNF2L or hISWI. Purification and peptide sequencing of the subunits of the complex revealed beta-actin as well as a novel actin-related protein, BAF53. beta-actin and BAF53 are required for maximal ATPase activity of BRG1 and are also required with BRG1 for association of the complex with chromatin/matrix. This work indicates that membrane signals control the activity of the mammalian SWI/SNF or BAF complex and demonstrates a direct interface between signaling and chromatin regulation.

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Metadata

Authors
Zhao, K., Wang, W., Rando, O. J., Xue, Y., Swiderek, K., Kuo, A., & Crabtree, G. R.
Venue
Cell
Publisher
Elsevier BV
Published
1998-11
Volume
95
Issue
5
Pages
625-636
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2085115632
Cited by
716
References
1
FWCI
10.92
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81633-5
The paper
Zhao, K., Wang, W., Rando, O. J., Xue, Y., Swiderek, K., Kuo, A., & Crabtree, G. R. (1998). Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling. Cell. https://doi.org/10.1016/s0092-8674(00)81633-5

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.