A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis
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In a culture system where a bifurcated Aplysia sensory neuron makes synapses with two motor neurons, repeated application of serotonin (5-HT) to one synapse produces a CREB-mediated, synapse-specific, long-term facilitation, which can be captured at the opposite synapse by a single pulse of 5-HT. Repeated pulses of 5-HT applied to the cell body of the sensory neuron produce a CREB-dependent, cell-wide facilitation, which, unlike synapse-specific facilitation, is not associated with growth and does not persist beyond 48 hr. Persistent facilitation and synapse-specific growth can be induced by a single pulse of 5-HT applied to a peripheral synapse. Thus, the short-term process initiated by a single pulse of 5-HT serves not only to produce transient facilitation, but also to mark and stabilize any synapse of the neuron for long-term facilitation by means of a covalent mark and rapamycin-sensitive local protein synthesis.
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Increased levels of CREB1 phosphorylation are associated with the induction and consolidation of LTF at sensorimotor synapses.
“For example, increased levels of CREB1 phosphorylation are associated with the induction and consolidation of LTF at sensorimotor synapses2,25,28.”
From Computational design of enhanced learning protocols (2012) · cites this paper as [25]
The induction and consolidation of LTF in vitro depends on the activity of several transcription factors.
“The induction and consolidation of LTF in vitro depends on the activity of several transcription factors24–27.”
From Computational design of enhanced learning protocols (2012) · cites this paper as [25]
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References 38 · Cited by 503
- Authors
- Casadio, A., Martin, K. C., Giustetto, M., Zhu, H., Chen, M., Bartsch, D., Bailey, C. H., & Kandel, E. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kandel, Eric R
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 99
- Issue
- 2
- Pages
- 221-237
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1987030209
- Cited by
- 503
- References
- 38
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 11 · 2019: 13 · 2018: 10 · 2017: 21 · 2016: 18 · 2015: 18 · 2014: 24 · 2013: 17 · 2012: 22
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-37134, R01MH037134)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- CREB, long-term facilitation, synaptic plasticity, local protein synthesis, serotonin, synaptic growth, rapamycin
- MeSH terms
- Animals, Aplysia, Cells, Cultured, Dactinomycin, Gene Expression Regulation, Memory, Motor Neurons, Nerve Tissue Proteins, Neurons, Afferent, Serotonin, Synapses, Protein Biosynthesis, Cyclic AMP Response Element-Binding Protein, Long-Term Potentiation, Excitatory Postsynaptic Potentials, Sirolimus
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